The Intestinal Epithelium at the Forefront of Host–Helminth Interactions

Gillian Coakley, Nicola L. Harris

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Gastrointestinal helminth infection still constitutes a major public health issue, particularly in the developing world. As these parasites can undergo a large part of their lifecycle within the intestinal tract the host has developed various structural and cellular specializations at the epithelial barrier to contend with infection. Detailed characterization of these cells will provide important insights about their contributions to the protective responses mediated against helminths. Here, we discuss how key components of the intestinal epithelium may function to limit the initial establishment of helminths, and how these cells are altered during an active response to infection.

Original languageEnglish
Pages (from-to)761-772
Number of pages12
JournalTrends in Parasitology
Volume36
Issue number9
DOIs
Publication statusPublished - Sep 2020

Keywords

  • enteroendocrine cell
  • goblet cell
  • helminth
  • intestinal epithelium
  • tuft cell
  • type 2 immunity

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