The interplay between antiviral immunity and allo-immune reactivity after renal transplantation. Consortium between the Centres Amsterdam, Leiden and Nijmegen (ALLOVIR)

Ineke ten Berge, Kirstin Heutinck, Unsal Yapici, Geurt Stokman, Sandrine Florquin, Cees van Kooten, G. Garcia-Romo, Jurjen Ruben, Mathijs van de Vrie, Luuk Hilbrands, Clive Michelo, Irma Joosten, Heleen van den Heuvel, Frans HJ Claas

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Abstract

In the consortium "ALLOVIR" we aim to characterize the effect of CMV and BKV infections on the innate immune responses to viral and alloantigens. Furthermore, we want to characterize the interplay between adaptive immune responses to viral and alloantigens with emphasis on the role of heterologous immunity. Thirdly, we will characterize the manifestations of these immune responses in the allograft, as reflected in tissue and urine, and their correlation with graft function. Finally, we will assess how immunosuppressive drugs interfere with these cross-reactive immune responses.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalTransplant Immunology
Volume31
Issue number4
DOIs
Publication statusPublished - 1 Oct 2014
Externally publishedYes

Keywords

  • Alloresponse
  • BKV
  • CMV
  • Cross-reactivity
  • Heterologous immunity
  • Renal transplantation

Cite this

ten Berge, I., Heutinck, K., Yapici, U., Stokman, G., Florquin, S., van Kooten, C., Garcia-Romo, G., Ruben, J., van de Vrie, M., Hilbrands, L., Michelo, C., Joosten, I., van den Heuvel, H., & Claas, F. HJ. (2014). The interplay between antiviral immunity and allo-immune reactivity after renal transplantation. Consortium between the Centres Amsterdam, Leiden and Nijmegen (ALLOVIR). Transplant Immunology, 31(4), 191-194. https://doi.org/10.1016/j.trim.2014.09.004