TY - JOUR
T1 - The interplay between antiviral immunity and allo-immune reactivity after renal transplantation. Consortium between the Centres Amsterdam, Leiden and Nijmegen (ALLOVIR)
AU - ten Berge, Ineke
AU - Heutinck, Kirstin
AU - Yapici, Unsal
AU - Stokman, Geurt
AU - Florquin, Sandrine
AU - van Kooten, Cees
AU - Garcia-Romo, G.
AU - Ruben, Jurjen
AU - van de Vrie, Mathijs
AU - Hilbrands, Luuk
AU - Michelo, Clive
AU - Joosten, Irma
AU - van den Heuvel, Heleen
AU - Claas, Frans HJ
PY - 2014/10/1
Y1 - 2014/10/1
N2 - In the consortium "ALLOVIR" we aim to characterize the effect of CMV and BKV infections on the innate immune responses to viral and alloantigens. Furthermore, we want to characterize the interplay between adaptive immune responses to viral and alloantigens with emphasis on the role of heterologous immunity. Thirdly, we will characterize the manifestations of these immune responses in the allograft, as reflected in tissue and urine, and their correlation with graft function. Finally, we will assess how immunosuppressive drugs interfere with these cross-reactive immune responses.
AB - In the consortium "ALLOVIR" we aim to characterize the effect of CMV and BKV infections on the innate immune responses to viral and alloantigens. Furthermore, we want to characterize the interplay between adaptive immune responses to viral and alloantigens with emphasis on the role of heterologous immunity. Thirdly, we will characterize the manifestations of these immune responses in the allograft, as reflected in tissue and urine, and their correlation with graft function. Finally, we will assess how immunosuppressive drugs interfere with these cross-reactive immune responses.
KW - Alloresponse
KW - BKV
KW - CMV
KW - Cross-reactivity
KW - Heterologous immunity
KW - Renal transplantation
UR - http://www.scopus.com/inward/record.url?scp=84919834534&partnerID=8YFLogxK
U2 - 10.1016/j.trim.2014.09.004
DO - 10.1016/j.trim.2014.09.004
M3 - Article
AN - SCOPUS:84919834534
VL - 31
SP - 191
EP - 194
JO - Transplant Immunology
JF - Transplant Immunology
SN - 0966-3274
IS - 4
ER -