The interplay between antiviral immunity and allo-immune reactivity after renal transplantation. Consortium between the Centres Amsterdam, Leiden and Nijmegen (ALLOVIR)

Ineke ten Berge; Kirstin Heutinck; Unsal Yapici; Geurt Stokman; Sandrine Florquin; Cees van Kooten; G. Garcia-Romo; Jurjen Ruben; Mathijs van de Vrie; Luuk Hilbrands; Clive Michelo; Irma Joosten; Heleen van den Heuvel; Frans HJ Claas

doi:10.1016/j.trim.2014.09.004

The interplay between antiviral immunity and allo-immune reactivity after renal transplantation. Consortium between the Centres Amsterdam, Leiden and Nijmegen (ALLOVIR)

Ineke ten Berge, Kirstin Heutinck, Unsal Yapici, Geurt Stokman, Sandrine Florquin, Cees van Kooten, G. Garcia-Romo, Jurjen Ruben, Mathijs van de Vrie, Luuk Hilbrands, Clive Michelo, Irma Joosten, Heleen van den Heuvel, Frans HJ Claas

Research output: Contribution to journal › Article › Other › peer-review

2 Citations (Scopus)

Abstract

In the consortium "ALLOVIR" we aim to characterize the effect of CMV and BKV infections on the innate immune responses to viral and alloantigens. Furthermore, we want to characterize the interplay between adaptive immune responses to viral and alloantigens with emphasis on the role of heterologous immunity. Thirdly, we will characterize the manifestations of these immune responses in the allograft, as reflected in tissue and urine, and their correlation with graft function. Finally, we will assess how immunosuppressive drugs interfere with these cross-reactive immune responses.

Original language	English
Pages (from-to)	191-194
Number of pages	4
Journal	Transplant Immunology
Volume	31
Issue number	4
DOIs	https://doi.org/10.1016/j.trim.2014.09.004
Publication status	Published - 1 Oct 2014
Externally published	Yes

Keywords

Alloresponse
BKV
CMV
Cross-reactivity
Heterologous immunity
Renal transplantation

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10.1016/j.trim.2014.09.004

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ten Berge, I., Heutinck, K., Yapici, U., Stokman, G., Florquin, S., van Kooten, C., Garcia-Romo, G., Ruben, J., van de Vrie, M., Hilbrands, L., Michelo, C., Joosten, I., van den Heuvel, H., & Claas, F. HJ. (2014). The interplay between antiviral immunity and allo-immune reactivity after renal transplantation. Consortium between the Centres Amsterdam, Leiden and Nijmegen (ALLOVIR). Transplant Immunology, 31(4), 191-194. https://doi.org/10.1016/j.trim.2014.09.004

ten Berge, Ineke ; Heutinck, Kirstin ; Yapici, Unsal ; Stokman, Geurt ; Florquin, Sandrine ; van Kooten, Cees ; Garcia-Romo, G. ; Ruben, Jurjen ; van de Vrie, Mathijs ; Hilbrands, Luuk ; Michelo, Clive ; Joosten, Irma ; van den Heuvel, Heleen ; Claas, Frans HJ. / The interplay between antiviral immunity and allo-immune reactivity after renal transplantation. Consortium between the Centres Amsterdam, Leiden and Nijmegen (ALLOVIR). In: Transplant Immunology. 2014 ; Vol. 31, No. 4. pp. 191-194.

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abstract = "In the consortium {"}ALLOVIR{"} we aim to characterize the effect of CMV and BKV infections on the innate immune responses to viral and alloantigens. Furthermore, we want to characterize the interplay between adaptive immune responses to viral and alloantigens with emphasis on the role of heterologous immunity. Thirdly, we will characterize the manifestations of these immune responses in the allograft, as reflected in tissue and urine, and their correlation with graft function. Finally, we will assess how immunosuppressive drugs interfere with these cross-reactive immune responses.",

keywords = "Alloresponse, BKV, CMV, Cross-reactivity, Heterologous immunity, Renal transplantation",

author = "{ten Berge}, Ineke and Kirstin Heutinck and Unsal Yapici and Geurt Stokman and Sandrine Florquin and {van Kooten}, Cees and G. Garcia-Romo and Jurjen Ruben and {van de Vrie}, Mathijs and Luuk Hilbrands and Clive Michelo and Irma Joosten and {van den Heuvel}, Heleen and Claas, {Frans HJ}",

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doi = "10.1016/j.trim.2014.09.004",

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ten Berge, I, Heutinck, K, Yapici, U, Stokman, G, Florquin, S, van Kooten, C, Garcia-Romo, G, Ruben, J, van de Vrie, M, Hilbrands, L, Michelo, C, Joosten, I, van den Heuvel, H & Claas, FHJ 2014, 'The interplay between antiviral immunity and allo-immune reactivity after renal transplantation. Consortium between the Centres Amsterdam, Leiden and Nijmegen (ALLOVIR)', Transplant Immunology, vol. 31, no. 4, pp. 191-194. https://doi.org/10.1016/j.trim.2014.09.004

The interplay between antiviral immunity and allo-immune reactivity after renal transplantation. Consortium between the Centres Amsterdam, Leiden and Nijmegen (ALLOVIR). / ten Berge, Ineke; Heutinck, Kirstin; Yapici, Unsal; Stokman, Geurt; Florquin, Sandrine; van Kooten, Cees; Garcia-Romo, G.; Ruben, Jurjen; van de Vrie, Mathijs; Hilbrands, Luuk; Michelo, Clive; Joosten, Irma; van den Heuvel, Heleen; Claas, Frans HJ.

In: Transplant Immunology, Vol. 31, No. 4, 01.10.2014, p. 191-194.

Research output: Contribution to journal › Article › Other › peer-review

TY - JOUR

T1 - The interplay between antiviral immunity and allo-immune reactivity after renal transplantation. Consortium between the Centres Amsterdam, Leiden and Nijmegen (ALLOVIR)

AU - ten Berge, Ineke

AU - Heutinck, Kirstin

AU - Yapici, Unsal

AU - Stokman, Geurt

AU - Florquin, Sandrine

AU - van Kooten, Cees

AU - Garcia-Romo, G.

AU - Ruben, Jurjen

AU - van de Vrie, Mathijs

AU - Hilbrands, Luuk

AU - Michelo, Clive

AU - Joosten, Irma

AU - van den Heuvel, Heleen

AU - Claas, Frans HJ

PY - 2014/10/1

Y1 - 2014/10/1

N2 - In the consortium "ALLOVIR" we aim to characterize the effect of CMV and BKV infections on the innate immune responses to viral and alloantigens. Furthermore, we want to characterize the interplay between adaptive immune responses to viral and alloantigens with emphasis on the role of heterologous immunity. Thirdly, we will characterize the manifestations of these immune responses in the allograft, as reflected in tissue and urine, and their correlation with graft function. Finally, we will assess how immunosuppressive drugs interfere with these cross-reactive immune responses.

AB - In the consortium "ALLOVIR" we aim to characterize the effect of CMV and BKV infections on the innate immune responses to viral and alloantigens. Furthermore, we want to characterize the interplay between adaptive immune responses to viral and alloantigens with emphasis on the role of heterologous immunity. Thirdly, we will characterize the manifestations of these immune responses in the allograft, as reflected in tissue and urine, and their correlation with graft function. Finally, we will assess how immunosuppressive drugs interfere with these cross-reactive immune responses.

KW - Alloresponse

KW - BKV

KW - CMV

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JO - Transplant Immunology

JF - Transplant Immunology

SN - 0966-3274

IS - 4

ER -

The interplay between antiviral immunity and allo-immune reactivity after renal transplantation. Consortium between the Centres Amsterdam, Leiden and Nijmegen (ALLOVIR)

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Keywords

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