The INTEROCC case-control study: Risk of meningioma and occupational exposure to selected combustion products, dusts and other chemical agents

Damien M. McElvenny, Martie Van Tongeren, Michelle C. Turner, Geza Benke, Jordi Figuerola, Sarah Fleming, Martine Hours, Laurel Kincl, Daniel Krewski, Dave McLean, Marie Élise Parent, Lesley Richardson, Brigitte Schlehofer, Klaus Schlaefer, Siegal Sadetzki, Joachim Schüz, Jack Siemiatycki, Elisabeth Cardis

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The INTEROCC study, an international case-control study of brain cancer conducted in seven countries, was conducted to evaluated whether risk of meningioma is associated with several occupational exposures. A job exposure matrix was employed to derive estimates of exposure for various agents, including asbestos, benzo(a)pyrene, bitumen, diesel and gasoline engine exhaust, formaldehyde, oil mist, PAH, and SO2. Most agents examined did not provoke excess risks of meningioma. Occupational exposure to mineral oil appeared to be associated with elevated risk of meningioma. Among women, there was also some indication of exposure-response for asbestos and some indication of excess risks from formaldehyde in the highest exposure categories. No association was observed with other occupational substances investigated, which included combustion products, mineral and organic dusts, and other chemical agents.

Original languageEnglish
Pages (from-to)12-22
Number of pages11
JournalOccupational and Environmental Medicine
Issue number1
Publication statusPublished - 2018

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