TY - JOUR
T1 - The interactions between MRI-detected osteophytes and bone marrow lesions or effusion-synovitis on knee symptom progression
T2 - an exploratory study
AU - Fan, T.
AU - Ruan, G.
AU - Antony, B.
AU - Cao, P.
AU - Li, J.
AU - Han, W.
AU - Li, Y.
AU - Yung, S. N.
AU - Wluka, A. E.
AU - Winzenberg, T.
AU - Cicuttini, F.
AU - Ding, C.
AU - Zhu, Z.
N1 - Funding Information:
Australia National Health and Medical Research Council Grant (Grant Number 605501); Clinical Research Startup Program of Southern Medical University, provided by High-level University Construction Funding of Guangdong Provincial Department of Education (NO. LC2019ZD015); Science and Technology Program of Guangzhou, China NO. 202002030481; Wu Jieping Medical Foundation Program, NO. 3206750.
Funding Information:
Australia National Health and Medical Research Council Grant (Grant Number 605501 ); Clinical Research Startup Program of Southern Medical University , provided by High-level University Construction Funding of Guangdong Provincial Department of Education (NO. LC2019ZD015 ); Science and Technology Program of Guangzhou , China NO. 202002030481; Wu Jieping Medical Foundation Program, NO. 3206750.
Publisher Copyright:
© 2021 Osteoarthritis Research Society International
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/9
Y1 - 2021/9
N2 - Objectives: To investigate the longitudinal association between MRI-detected osteophyte scores and progression of knee symptoms, and whether the association was modified in the presence of bone marrow lesions (BMLs) or effusion-synovitis. Methods: Data from Vitamin D Effects on Osteoarthritis (VIDEO) study, a randomized, double-blinded and placebo-controlled clinical trial in symptomatic knee osteoarthritis (OA) patients, were analyzed as an exploratory study. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used to assess knee symptoms. Osteophytes, BMLs and effusion-synovitis were measured using MRI. Results: 334 participants with MRI information and WOMAC score (baseline and follow-up) were included in the analyses, with 24.3% of them having knee pain increased 2 years later. Statistically significant interactions were found between MRI-detected osteophytes and BMLs or effusion-synovitis on increased knee symptoms. In participants with BMLs, higher baseline scores of MRI-detected osteophytes in most compartments were significantly associated with increased total knee pain, weight-bearing pain, stiffness, and physical dysfunction, after adjustment for age, sex, body mass index, intervention and effusion-synovitis. In participants with effusion-synovitis, higher baseline scores of MRI-detected osteophytes in almost all the compartments were significantly associated with increased total knee pain, weight-bearing pain, stiffness, and physical dysfunction, after adjustment for age, sex, body mass index, intervention and BMLs. In contrast, MRI-detected osteophyte scores were generally not associated with knee symptom progression in participants without baseline BMLs or effusion-synovitis. Conclusions: MRI-detected OPs are associated with increased total knee pain, weight-bearing knee pain, stiffness and physical dysfunction in participants presenting BMLs or effusion-synovitis, but not in participants lacking BMLs or effusion-synovitis. This suggests they could interact with bone or synovial abnormalities to induce symptoms in knee OA.
AB - Objectives: To investigate the longitudinal association between MRI-detected osteophyte scores and progression of knee symptoms, and whether the association was modified in the presence of bone marrow lesions (BMLs) or effusion-synovitis. Methods: Data from Vitamin D Effects on Osteoarthritis (VIDEO) study, a randomized, double-blinded and placebo-controlled clinical trial in symptomatic knee osteoarthritis (OA) patients, were analyzed as an exploratory study. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used to assess knee symptoms. Osteophytes, BMLs and effusion-synovitis were measured using MRI. Results: 334 participants with MRI information and WOMAC score (baseline and follow-up) were included in the analyses, with 24.3% of them having knee pain increased 2 years later. Statistically significant interactions were found between MRI-detected osteophytes and BMLs or effusion-synovitis on increased knee symptoms. In participants with BMLs, higher baseline scores of MRI-detected osteophytes in most compartments were significantly associated with increased total knee pain, weight-bearing pain, stiffness, and physical dysfunction, after adjustment for age, sex, body mass index, intervention and effusion-synovitis. In participants with effusion-synovitis, higher baseline scores of MRI-detected osteophytes in almost all the compartments were significantly associated with increased total knee pain, weight-bearing pain, stiffness, and physical dysfunction, after adjustment for age, sex, body mass index, intervention and BMLs. In contrast, MRI-detected osteophyte scores were generally not associated with knee symptom progression in participants without baseline BMLs or effusion-synovitis. Conclusions: MRI-detected OPs are associated with increased total knee pain, weight-bearing knee pain, stiffness and physical dysfunction in participants presenting BMLs or effusion-synovitis, but not in participants lacking BMLs or effusion-synovitis. This suggests they could interact with bone or synovial abnormalities to induce symptoms in knee OA.
KW - Knee osteoarthritis
KW - Knee pain
KW - Knee structures abnormalities
KW - Magnetic resonance imaging
KW - Osteophytes
UR - http://www.scopus.com/inward/record.url?scp=85110559797&partnerID=8YFLogxK
U2 - 10.1016/j.joca.2021.06.008
DO - 10.1016/j.joca.2021.06.008
M3 - Article
C2 - 34216729
AN - SCOPUS:85110559797
SN - 1063-4584
VL - 29
SP - 1296
EP - 1305
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
IS - 9
ER -