The ins and outs of phosphosignalling in Plasmodium: Parasite regulation and host cell manipulation

Teresa Gil Carvalho, Belinda Morahan, Simona John von Freyend, Phillippe Boeuf, Georges Grau, Jose Garcia-Bustos, Christian Doerig

Research output: Contribution to journalReview ArticleOtherpeer-review

17 Citations (Scopus)

Abstract

Signal transduction and kinomics have been rapidly expanding areas of investigation within the malaria research field. Here, we provide an overview of phosphosignalling pathways that operate in all stages of the Plasmodium life cycle. We review signalling pathways in the parasite itself, in the cells it invades, and in other cells of the vertebrate host with which it interacts. We also discuss the potential of these pathways as novel targets for antimalarial intervention.
Original languageEnglish
Pages (from-to)2-15
Number of pages14
JournalMolecular and Biochemical Parasitology
Volume208
Issue number1
DOIs
Publication statusPublished - Jul 2016

Keywords

  • Malaria
  • Plasmodium
  • Protein kinase
  • Protein phosphatase
  • Phosphorylation
  • Signalling

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