The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?

Megan Victoria Astle, Kristy Amanda Horan, Lisa Michelle Ooms, Christina Anne Mitchell

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Abstract

Phosphoinositide signals regulate cell proliferation, differentiation, cytoskeletal rearrangement and intracellular trafficking. Hydrolysis of PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3), by inositol polyphosphate 5-phosphatases regulates synaptic vesicle recycling (synaptojanin-1), hematopoietic cell function [SHIP1(SH2-containing inositol polyphosphate 5-phosphatase-1)], renal cell function [OCRL (oculocerebrorenal syndrome of Lowe)] and insulin signalling (SHIP2). We present here a detailed review of the characteristics of the ten mammalian 5-phosphatases. Knockout mouse phenotypes and underexpression studies are associated with significant phenotypic changes, indicating non-redundant roles, despite, in many cases, overlapping substrate specificity and tissue expression. The extraordinary complexity in the control of phosphoinositide signalling continues to be revealed.
Original languageEnglish
Pages (from-to)161 - 181
Number of pages21
JournalBiochemical Society Symposium
Publication statusPublished - 2007

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