The influence of physical activity on vascular complications and mortality in patients with type 2 diabetes mellitus

J I Blomster, Clara Chow, Sophia Zoungas, Mark Woodward, Anushka Patel, Neil R Poulter, Michel Marre, Stephen B Harrap, John P Chalmers, Graham Hillis

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There is limited evidence regarding the association between physical activity and vascular complications, particularly microvascular disease, in patients with type 2 diabetes. Methods: From the 11140 patients in the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron modified release Controlled Evaluation) trial, the effect of physical activity, categorized as none, mild, moderate or vigorous, and the number of sessions within a week, was examined in multivariable regression models adjusted for potential confounders. The study end-points were major cardiovascular events, microvascular complications and all-cause mortality. Results: Forty-six percent of participants reported undertaking moderate to vigorous physical activity for >15min at least once in the previous week. During a median of 5years of follow-up, 1031 patients died, 1147 experienced a major cardiovascular event and 1136 a microvascular event. Compared to patients who undertook no or mild physical activity, those reporting moderate to vigorous activity had a decreased risk of cardiovascular events (HR: 0.78, 95 CI: 0.69-0.88, p
Original languageEnglish
Pages (from-to)1008 - 1012
Number of pages5
JournalDiabetes, Obesity and Metabolism
Issue number11
Publication statusPublished - 2013

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