The Influence of Pharmacological Autonomic Blockades on Multi-Scale Measures of Heart Rate Variability

F. Marzbanrad, C. K. Karmakar, A. H. Khandoker, M. Palaniswami, T Moritani, H. F. Jelinek

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Multi-scale measures have been used extensively to characterize non-linear dynamics of heart beats. However a physiological interpretation of the exponents associated with various scales of these measures and the role of the sympathetic and parasympathetic activities have not been attempted. In this study three multi-scale measures were compared at different scales in a pharmacological autonomic blockade experiment, starting with a control phase. It was then followed by injection of propranolol causing sympathetic blockade and injection of atropine resulting in the blockade of both sympathetic and parasympathetic pathways. Multiscale Entropy (MSE), Multi Fractal Detrended Fluctuation Analysis (MFDFA) and Renyi Entropy (RE) were compared using a paired test statistics. The measures performed differently depending on the scale factors and RE showed the best results indicating a good discrimination particularly at higher scale exponents. This study provides a basis for understanding the effect of autonomic activity on multiscale measures with respect to changes in parasympathetic and sympathetic activity.
Original languageEnglish
Title of host publicationEMBEC & NBC 2017
Subtitle of host publicationJoint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC), Tampere, Finland, June 2017
EditorsHannu Eskola, Jari Viik, Outi Väisänen, Jari Hyttinen
Place of PublicationSingapore, Singapore
Number of pages4
ISBN (Electronic)9789811051227
ISBN (Print)9789811051210
Publication statusPublished - 13 Jun 2017
EventJoint Conference of the EMBEC and NBC - Tampere, Finland
Duration: 11 Jun 201715 Jun 2017

Publication series

NameIFMBE Proceedings
ISSN (Print)1680-0737
ISSN (Electronic)1433-9277


ConferenceJoint Conference of the EMBEC and NBC


  • Autonomic Blockades
  • Autonomic Nervous System
  • Entropy
  • Heart Rate Variability
  • Multi-Scale

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