The Influence of Pharmacological Autonomic Blockades on Multi-Scale Measures of Heart Rate Variability

F. Marzbanrad; C. K. Karmakar; A. H. Khandoker; M. Palaniswami; T Moritani; H. F. Jelinek

doi:10.1007/978-981-10-5122-7_116

The Influence of Pharmacological Autonomic Blockades on Multi-Scale Measures of Heart Rate Variability

F. Marzbanrad, C. K. Karmakar, A. H. Khandoker, M. Palaniswami, T Moritani, H. F. Jelinek

Electrical and Computer Systems Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

Abstract

Multi-scale measures have been used extensively to characterize non-linear dynamics of heart beats. However a physiological interpretation of the exponents associated with various scales of these measures and the role of the sympathetic and parasympathetic activities have not been attempted. In this study three multi-scale measures were compared at different scales in a pharmacological autonomic blockade experiment, starting with a control phase. It was then followed by injection of propranolol causing sympathetic blockade and injection of atropine resulting in the blockade of both sympathetic and parasympathetic pathways. Multiscale Entropy (MSE), Multi Fractal Detrended Fluctuation Analysis (MFDFA) and Renyi Entropy (RE) were compared using a paired test statistics. The measures performed differently depending on the scale factors and RE showed the best results indicating a good discrimination particularly at higher scale exponents. This study provides a basis for understanding the effect of autonomic activity on multiscale measures with respect to changes in parasympathetic and sympathetic activity.

Original language	English
Title of host publication	EMBEC & NBC 2017
Subtitle of host publication	Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC), Tampere, Finland, June 2017
Editors	Hannu Eskola, Jari Viik, Outi Väisänen, Jari Hyttinen
Place of Publication	Singapore, Singapore
Publisher	Springer
Pages	462-465
Number of pages	4
Volume	65
ISBN (Electronic)	9789811051227
ISBN (Print)	9789811051210
DOIs	https://doi.org/10.1007/978-981-10-5122-7_116
Publication status	Published - 13 Jun 2017
Event	Joint Conference of the EMBEC and NBC - Tampere, Finland Duration: 11 Jun 2017 → 15 Jun 2017

Publication series

Name	IFMBE Proceedings
Publisher	Springer
Volume	65
ISSN (Print)	1680-0737
ISSN (Electronic)	1433-9277

Conference

Conference	Joint Conference of the EMBEC and NBC
Country/Territory	Finland
City	Tampere
Period	11/06/17 → 15/06/17

Keywords

Autonomic Blockades
Autonomic Nervous System
Entropy
Heart Rate Variability
Multi-Scale

Access to Document

10.1007/978-981-10-5122-7_116

Cite this

Marzbanrad, F., Karmakar, C. K., Khandoker, A. H., Palaniswami, M., Moritani, T., & Jelinek, H. F. (2017). The Influence of Pharmacological Autonomic Blockades on Multi-Scale Measures of Heart Rate Variability. In H. Eskola, J. Viik, O. Väisänen, & J. Hyttinen (Eds.), EMBEC & NBC 2017: Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC), Tampere, Finland, June 2017 (Vol. 65, pp. 462-465). (IFMBE Proceedings; Vol. 65). Springer. https://doi.org/10.1007/978-981-10-5122-7_116

Marzbanrad, F. ; Karmakar, C. K. ; Khandoker, A. H. et al. / The Influence of Pharmacological Autonomic Blockades on Multi-Scale Measures of Heart Rate Variability. EMBEC & NBC 2017: Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC), Tampere, Finland, June 2017. editor / Hannu Eskola ; Jari Viik ; Outi Väisänen ; Jari Hyttinen. Vol. 65 Singapore, Singapore : Springer, 2017. pp. 462-465 (IFMBE Proceedings).

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abstract = "Multi-scale measures have been used extensively to characterize non-linear dynamics of heart beats. However a physiological interpretation of the exponents associated with various scales of these measures and the role of the sympathetic and parasympathetic activities have not been attempted. In this study three multi-scale measures were compared at different scales in a pharmacological autonomic blockade experiment, starting with a control phase. It was then followed by injection of propranolol causing sympathetic blockade and injection of atropine resulting in the blockade of both sympathetic and parasympathetic pathways. Multiscale Entropy (MSE), Multi Fractal Detrended Fluctuation Analysis (MFDFA) and Renyi Entropy (RE) were compared using a paired test statistics. The measures performed differently depending on the scale factors and RE showed the best results indicating a good discrimination particularly at higher scale exponents. This study provides a basis for understanding the effect of autonomic activity on multiscale measures with respect to changes in parasympathetic and sympathetic activity.",

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Marzbanrad, F, Karmakar, CK, Khandoker, AH, Palaniswami, M, Moritani, T & Jelinek, HF 2017, The Influence of Pharmacological Autonomic Blockades on Multi-Scale Measures of Heart Rate Variability. in H Eskola, J Viik, O Väisänen & J Hyttinen (eds), EMBEC & NBC 2017: Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC), Tampere, Finland, June 2017. vol. 65, IFMBE Proceedings, vol. 65, Springer, Singapore, Singapore, pp. 462-465, Joint Conference of the EMBEC and NBC, Tampere, Finland, 11/06/17. https://doi.org/10.1007/978-981-10-5122-7_116

The Influence of Pharmacological Autonomic Blockades on Multi-Scale Measures of Heart Rate Variability. / Marzbanrad, F.; Karmakar, C. K.; Khandoker, A. H. et al.
EMBEC & NBC 2017: Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC), Tampere, Finland, June 2017. ed. / Hannu Eskola; Jari Viik; Outi Väisänen; Jari Hyttinen. Vol. 65 Singapore, Singapore: Springer, 2017. p. 462-465 (IFMBE Proceedings; Vol. 65).

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

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AU - Palaniswami, M.

AU - Moritani, T

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N2 - Multi-scale measures have been used extensively to characterize non-linear dynamics of heart beats. However a physiological interpretation of the exponents associated with various scales of these measures and the role of the sympathetic and parasympathetic activities have not been attempted. In this study three multi-scale measures were compared at different scales in a pharmacological autonomic blockade experiment, starting with a control phase. It was then followed by injection of propranolol causing sympathetic blockade and injection of atropine resulting in the blockade of both sympathetic and parasympathetic pathways. Multiscale Entropy (MSE), Multi Fractal Detrended Fluctuation Analysis (MFDFA) and Renyi Entropy (RE) were compared using a paired test statistics. The measures performed differently depending on the scale factors and RE showed the best results indicating a good discrimination particularly at higher scale exponents. This study provides a basis for understanding the effect of autonomic activity on multiscale measures with respect to changes in parasympathetic and sympathetic activity.

AB - Multi-scale measures have been used extensively to characterize non-linear dynamics of heart beats. However a physiological interpretation of the exponents associated with various scales of these measures and the role of the sympathetic and parasympathetic activities have not been attempted. In this study three multi-scale measures were compared at different scales in a pharmacological autonomic blockade experiment, starting with a control phase. It was then followed by injection of propranolol causing sympathetic blockade and injection of atropine resulting in the blockade of both sympathetic and parasympathetic pathways. Multiscale Entropy (MSE), Multi Fractal Detrended Fluctuation Analysis (MFDFA) and Renyi Entropy (RE) were compared using a paired test statistics. The measures performed differently depending on the scale factors and RE showed the best results indicating a good discrimination particularly at higher scale exponents. This study provides a basis for understanding the effect of autonomic activity on multiscale measures with respect to changes in parasympathetic and sympathetic activity.

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Marzbanrad F, Karmakar CK, Khandoker AH, Palaniswami M, Moritani T, Jelinek HF. The Influence of Pharmacological Autonomic Blockades on Multi-Scale Measures of Heart Rate Variability. In Eskola H, Viik J, Väisänen O, Hyttinen J, editors, EMBEC & NBC 2017: Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC), Tampere, Finland, June 2017. Vol. 65. Singapore, Singapore: Springer. 2017. p. 462-465. (IFMBE Proceedings). doi: 10.1007/978-981-10-5122-7_116

The Influence of Pharmacological Autonomic Blockades on Multi-Scale Measures of Heart Rate Variability

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