The Influence of Crystalline Morphology and Copolymer Composition on Drug Release from Solution Cast and Melt-Processed P(Hb-Hv) Copolymer Matrices: Journal of Controlled Release

S. Akhtar, C. W. Pouton, L. J. Notarianni

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Crystalline poly-D(-)-3-hydroxybutyrate (PHB) and its copolymers with poly-3-hydroxyvalerate [P(HB-HV)] are biodegradable polyhydroxyalkanoates with potential application in controlled drug delivery systems. Matrices of PHB and P(HB-HV) copolymers containing a model drug, methyl red, were prepared by solvent casting and melt-processing. Drug release from P(HB-HV) copolymer matrices produced by any given fabrication technique was dependent on copolymer composition. Progressively faster rates of drug release were obtained on increasing HV content. This could be explained by the different crystallization behaviour of P(HB-HV) copolymers. Evidence from polarized light microscopy of copolymer spherulites suggests that copolymer films with increasing HV content exhibit morphologies with decreasing abilities to entrap the model drug.
Original languageEnglish
Pages (from-to)225-233
Number of pages9
JournalJournal of Controlled Release
Publication statusPublished - 1991


  • polyhydroxybutyrate polyhydroxyvalerate crystalline morphology drug release biodegradable polyhydroxyalkanoates

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