The influence of airway resistance in the dynamic elastance model

Bernhard Laufer; J. Kretschmer; P. D. Docherty; Y. S. Chiew; K. Möller

doi:10.1007/978-3-319-32703-7_12

The influence of airway resistance in the dynamic elastance model

Bernhard Laufer, J. Kretschmer, P. D. Docherty, Y. S. Chiew, K. Möller

Malaysia School of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

1 Citation (Scopus)

Abstract

The selection of optimal positive end-expiratory pressure (PEEP) levels during ventilation therapy of patients with ARDS (acute respiratory distress syndrome) remains a problem for clinicians. A particular mooted strategy states that minimizing the energy transferred to the lung during mechanical ventilation could potentially be used to determine the optimal, patient-specific PEEP levels. The dynamic elastance model of pulmonary mechanics could potentially be used to minimize the energy by localization of the patients’ minimum dynamic elastance range. The sensitivity of the dynamic elastance model to variance in the airway resistance was analyzed. Subsequently, the airway resistance was determined using two alternate identification methods and was compared to the constant resistance obtained using the dynamic elastance model. Both identification methods showed similar decreasing trends of the resistance during inspiration. This declining trend is an apparent exponential decrease. Results showed that the constant airway resistance, presumed by the dynamic elastance model, has to be rechecked and investigated.

Original language	English
Title of host publication	XIV Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2016
Editors	Efthyvoulos Kyriacou, Stelios Christofides, Constantinos S. Pattichis
Publisher	Springer
Pages	56-61
Number of pages	6
ISBN (Print)	9783319327013
DOIs	https://doi.org/10.1007/978-3-319-32703-7_12
Publication status	Published - 2016
Event	Mediterranean Conference on Medical and Biological Engineering and Computing 2016 - Paphos, Cyprus Duration: 31 Mar 2016 → 2 Apr 2016 Conference number: 14th https://link.springer.com/book/10.1007/978-3-319-32703-7 (Proceedings)

Publication series

Name	IFMBE Proceedings
Volume	57
ISSN (Print)	1680-0737

Conference

Conference	Mediterranean Conference on Medical and Biological Engineering and Computing 2016
Abbreviated title	MEDICON 2016
Country/Territory	Cyprus
City	Paphos
Period	31/03/16 → 2/04/16
Internet address	https://link.springer.com/book/10.1007/978-3-319-32703-7 (Proceedings)

Keywords

First order model
Lung Mechanics
Mechanical Ventilation
Physiological Modelling

Access to Document

10.1007/978-3-319-32703-7_12

Cite this

Laufer, B., Kretschmer, J., Docherty, P. D., Chiew, Y. S., & Möller, K. (2016). The influence of airway resistance in the dynamic elastance model. In E. Kyriacou, S. Christofides, & C. S. Pattichis (Eds.), XIV Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2016 (pp. 56-61). (IFMBE Proceedings; Vol. 57). Springer. https://doi.org/10.1007/978-3-319-32703-7_12

@inproceedings{742da5d369d5402c8daefd9e5a887d4d,

title = "The influence of airway resistance in the dynamic elastance model",

abstract = "The selection of optimal positive end-expiratory pressure (PEEP) levels during ventilation therapy of patients with ARDS (acute respiratory distress syndrome) remains a problem for clinicians. A particular mooted strategy states that minimizing the energy transferred to the lung during mechanical ventilation could potentially be used to determine the optimal, patient-specific PEEP levels. The dynamic elastance model of pulmonary mechanics could potentially be used to minimize the energy by localization of the patients{\textquoteright} minimum dynamic elastance range. The sensitivity of the dynamic elastance model to variance in the airway resistance was analyzed. Subsequently, the airway resistance was determined using two alternate identification methods and was compared to the constant resistance obtained using the dynamic elastance model. Both identification methods showed similar decreasing trends of the resistance during inspiration. This declining trend is an apparent exponential decrease. Results showed that the constant airway resistance, presumed by the dynamic elastance model, has to be rechecked and investigated.",

keywords = "First order model, Lung Mechanics, Mechanical Ventilation, Physiological Modelling",

author = "Bernhard Laufer and J. Kretschmer and Docherty, \{P. D.\} and Chiew, \{Y. S.\} and K. M{\"o}ller",

note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2016. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.; Mediterranean Conference on Medical and Biological Engineering and Computing 2016, MEDICON 2016 ; Conference date: 31-03-2016 Through 02-04-2016",

year = "2016",

doi = "10.1007/978-3-319-32703-7\_12",

language = "English",

isbn = "9783319327013",

series = "IFMBE Proceedings",

publisher = "Springer",

pages = "56--61",

editor = "Efthyvoulos Kyriacou and Stelios Christofides and Pattichis, \{Constantinos S.\}",

booktitle = "XIV Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2016",

address = "Switzerland",

url = "https://link.springer.com/book/10.1007/978-3-319-32703-7",

}

Laufer, B, Kretschmer, J, Docherty, PD, Chiew, YS & Möller, K 2016, The influence of airway resistance in the dynamic elastance model. in E Kyriacou, S Christofides & CS Pattichis (eds), XIV Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2016. IFMBE Proceedings, vol. 57, Springer, pp. 56-61, Mediterranean Conference on Medical and Biological Engineering and Computing 2016, Paphos, Cyprus, 31/03/16. https://doi.org/10.1007/978-3-319-32703-7_12

The influence of airway resistance in the dynamic elastance model. / Laufer, Bernhard; Kretschmer, J.; Docherty, P. D. et al.
XIV Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2016. ed. / Efthyvoulos Kyriacou; Stelios Christofides; Constantinos S. Pattichis. Springer, 2016. p. 56-61 (IFMBE Proceedings; Vol. 57).

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

TY - GEN

T1 - The influence of airway resistance in the dynamic elastance model

AU - Laufer, Bernhard

AU - Kretschmer, J.

AU - Docherty, P. D.

AU - Chiew, Y. S.

AU - Möller, K.

N1 - Conference code: 14th

PY - 2016

Y1 - 2016

N2 - The selection of optimal positive end-expiratory pressure (PEEP) levels during ventilation therapy of patients with ARDS (acute respiratory distress syndrome) remains a problem for clinicians. A particular mooted strategy states that minimizing the energy transferred to the lung during mechanical ventilation could potentially be used to determine the optimal, patient-specific PEEP levels. The dynamic elastance model of pulmonary mechanics could potentially be used to minimize the energy by localization of the patients’ minimum dynamic elastance range. The sensitivity of the dynamic elastance model to variance in the airway resistance was analyzed. Subsequently, the airway resistance was determined using two alternate identification methods and was compared to the constant resistance obtained using the dynamic elastance model. Both identification methods showed similar decreasing trends of the resistance during inspiration. This declining trend is an apparent exponential decrease. Results showed that the constant airway resistance, presumed by the dynamic elastance model, has to be rechecked and investigated.

AB - The selection of optimal positive end-expiratory pressure (PEEP) levels during ventilation therapy of patients with ARDS (acute respiratory distress syndrome) remains a problem for clinicians. A particular mooted strategy states that minimizing the energy transferred to the lung during mechanical ventilation could potentially be used to determine the optimal, patient-specific PEEP levels. The dynamic elastance model of pulmonary mechanics could potentially be used to minimize the energy by localization of the patients’ minimum dynamic elastance range. The sensitivity of the dynamic elastance model to variance in the airway resistance was analyzed. Subsequently, the airway resistance was determined using two alternate identification methods and was compared to the constant resistance obtained using the dynamic elastance model. Both identification methods showed similar decreasing trends of the resistance during inspiration. This declining trend is an apparent exponential decrease. Results showed that the constant airway resistance, presumed by the dynamic elastance model, has to be rechecked and investigated.

KW - First order model

KW - Lung Mechanics

KW - Mechanical Ventilation

KW - Physiological Modelling

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BT - XIV Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2016

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PB - Springer

T2 - Mediterranean Conference on Medical and Biological Engineering and Computing 2016

Y2 - 31 March 2016 through 2 April 2016

ER -

The influence of airway resistance in the dynamic elastance model

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Keywords

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