The incorporation of orally fed radioactive γ-linolenic acid and linoleic acid into the liver and brain lipids of suckling rats

A. G. Hassam; A. J. Sinclair; M. A. Cramwford

doi:10.1007/BF02532447

The incorporation of orally fed radioactive γ-linolenic acid and linoleic acid into the liver and brain lipids of suckling rats

A. G. Hassam, A. J. Sinclair, M. A. Cramwford

Research output: Contribution to journal › Article › Research › peer-review

73 Citations (Scopus)

Abstract

The incorporation of radioactivity from orally administered γ-linolenic acid-1-¹⁴C and linoleic acid-³H into the liver, plasma, and brain lipids of suckling rats was studied. Significantly more radioactivity from the former compound was incorporated into the liver and brain lipids 22 hr after dosing. The distribution of the radioactivity in the fatty acids of the liver and brain lipids was different for each isotope. Most of the³H was still associated with linoleic acid, whereas most of the¹⁴C was in the 20:3 and 20:4ω6 fractions. These results suggest that the desaturation of linoleic to γ-linolenic acid in vivo is a rate-limiting step in the conversion of linoleic to arachidonic acid.

Original language	English
Pages (from-to)	417-420
Number of pages	4
Journal	Lipids
Volume	10
Issue number	7
DOIs	https://doi.org/10.1007/BF02532447
Publication status	Published - 1 Jul 1975
Externally published	Yes

Access to Document

10.1007/BF02532447

Cite this

@article{2e1fbaf75f2f4d2598f0cf76b5cff535,

title = "The incorporation of orally fed radioactive γ-linolenic acid and linoleic acid into the liver and brain lipids of suckling rats",

abstract = "The incorporation of radioactivity from orally administered γ-linolenic acid-1-14C and linoleic acid-3H into the liver, plasma, and brain lipids of suckling rats was studied. Significantly more radioactivity from the former compound was incorporated into the liver and brain lipids 22 hr after dosing. The distribution of the radioactivity in the fatty acids of the liver and brain lipids was different for each isotope. Most of the3H was still associated with linoleic acid, whereas most of the14C was in the 20:3 and 20:4ω6 fractions. These results suggest that the desaturation of linoleic to γ-linolenic acid in vivo is a rate-limiting step in the conversion of linoleic to arachidonic acid.",

author = "Hassam, {A. G.} and Sinclair, {A. J.} and Cramwford, {M. A.}",

year = "1975",

month = jul,

day = "1",

doi = "10.1007/BF02532447",

language = "English",

volume = "10",

pages = "417--420",

journal = "Lipids",

issn = "0024-4201",

publisher = "Springer-Verlag London Ltd.",

number = "7",

}

TY - JOUR

T1 - The incorporation of orally fed radioactive γ-linolenic acid and linoleic acid into the liver and brain lipids of suckling rats

AU - Hassam, A. G.

AU - Sinclair, A. J.

AU - Cramwford, M. A.

PY - 1975/7/1

Y1 - 1975/7/1

N2 - The incorporation of radioactivity from orally administered γ-linolenic acid-1-14C and linoleic acid-3H into the liver, plasma, and brain lipids of suckling rats was studied. Significantly more radioactivity from the former compound was incorporated into the liver and brain lipids 22 hr after dosing. The distribution of the radioactivity in the fatty acids of the liver and brain lipids was different for each isotope. Most of the3H was still associated with linoleic acid, whereas most of the14C was in the 20:3 and 20:4ω6 fractions. These results suggest that the desaturation of linoleic to γ-linolenic acid in vivo is a rate-limiting step in the conversion of linoleic to arachidonic acid.

AB - The incorporation of radioactivity from orally administered γ-linolenic acid-1-14C and linoleic acid-3H into the liver, plasma, and brain lipids of suckling rats was studied. Significantly more radioactivity from the former compound was incorporated into the liver and brain lipids 22 hr after dosing. The distribution of the radioactivity in the fatty acids of the liver and brain lipids was different for each isotope. Most of the3H was still associated with linoleic acid, whereas most of the14C was in the 20:3 and 20:4ω6 fractions. These results suggest that the desaturation of linoleic to γ-linolenic acid in vivo is a rate-limiting step in the conversion of linoleic to arachidonic acid.

UR - http://www.scopus.com/inward/record.url?scp=0016733641&partnerID=8YFLogxK

U2 - 10.1007/BF02532447

DO - 10.1007/BF02532447

M3 - Article

C2 - 1143027

AN - SCOPUS:0016733641

SN - 0024-4201

VL - 10

SP - 417

EP - 420

JO - Lipids

JF - Lipids

IS - 7

ER -

The incorporation of orally fed radioactive γ-linolenic acid and linoleic acid into the liver and brain lipids of suckling rats

Abstract

Access to Document

Other files and links

Cite this