TY - JOUR
T1 - The importance of sex differences in pharmacology research
AU - Gogos, Andrea
AU - Langmead, Christopher
AU - Sullivan, Jennifer C.
AU - Lawrence, Andrew J.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - There still exists a sex bias in preclinical research where male subjects are primarily used. In this themed section of the British Journal of Pharmacology, we discuss why this problem exists and how it might contribute to translation and reproducibility issues in research. The articles here highlight sex differences in psychiatric disorders, addiction, dementias, metabolic diseases, and cardiovascular risk. The role of sex hormones, and inflammatory processes as mediators of the observed sex differences, is discussed. Given the variety of disorders highlighted in this issue that show sex differences, these articles underscore the importance of examining both sexes in research.
AB - There still exists a sex bias in preclinical research where male subjects are primarily used. In this themed section of the British Journal of Pharmacology, we discuss why this problem exists and how it might contribute to translation and reproducibility issues in research. The articles here highlight sex differences in psychiatric disorders, addiction, dementias, metabolic diseases, and cardiovascular risk. The role of sex hormones, and inflammatory processes as mediators of the observed sex differences, is discussed. Given the variety of disorders highlighted in this issue that show sex differences, these articles underscore the importance of examining both sexes in research.
UR - http://www.scopus.com/inward/record.url?scp=85075549200&partnerID=8YFLogxK
U2 - 10.1111/bph.14819
DO - 10.1111/bph.14819
M3 - Editorial
C2 - 31769019
AN - SCOPUS:85075549200
SN - 0007-1188
VL - 176
SP - 4087
EP - 4089
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
IS - 21
ER -