There still exists a sex bias in preclinical research where male subjects are primarily used. In this themed section of the British Journal of Pharmacology, we discuss why this problem exists and how it might contribute to translation and reproducibility issues in research. The articles here highlight sex differences in psychiatric disorders, addiction, dementias, metabolic diseases, and cardiovascular risk. The role of sex hormones, and inflammatory processes as mediators of the observed sex differences, is discussed. Given the variety of disorders highlighted in this issue that show sex differences, these articles underscore the importance of examining both sexes in research.
Gogos, A., Langmead, C., Sullivan, J. C., & Lawrence, A. J. (2019). The importance of sex differences in pharmacology research. British Journal of Pharmacology, 176(21), 4087-4089. https://doi.org/10.1111/bph.14819