The importance of regulatory RNAs in Staphylococcus aureus

Arnaud Tomasini, Patrice Francois, Benjamin Peter Howden, Pierre Fechter, Pascale Romby, Isabelle Caldelari

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26 Citations (Scopus)


RNA molecules with regulatory functions in pathogenic bacteria have benefited from a renewed interest these two last decades. In Staphylococcus aureus, recent genome-wide approaches have led to the discovery that almost 10-20 of genes code for RNAs with critical regulatory roles in adaptive processes. These RNAs include trans-acting RNAs, which mostly act through binding to target mRNAs, and cis-acting RNAs, which include regulatory regions of mRNAs responding to various metabolic signals. Besides recent analysis of S. aureus transcriptome has revealed an unprecedented existence of pervasive transcription generating a high number of weakly expressed antisense RNAs along the genome as well as numerous mRNAs with overlapped regions. Here, we will illustrate the diversity of trans-acting RNAs and illustrate how they are integrated into complex regulatory circuits, which link metabolism, stress response and virulence.
Original languageEnglish
Pages (from-to)616 - 626
Number of pages11
JournalInfection, Genetics and Evolution
Publication statusPublished - 2014

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