The importance of monocytes and macrophages in HIV pathogenesis,treatment,and cure

Jennifer H. Campbell, Anna C. Hearps, Genevieve E Martin, Kenneth C. Williams, Suzanne M. Crowe

Research output: Contribution to journalReview ArticleResearchpeer-review

78 Citations (Scopus)

Abstract

Monocytes and macrophages play critical roles in HIV transmission, viral spread early in infection, and as a reservoir of virus throughout infection. There has been a recent resurgence of interest in the biology of monocyte subsets and macrophages and their role in HIV pathogenesis, partly fuelled by efforts to understand difficulties in achieving HIV eradication. This article examines the importance of monocyte subsets and tissue macrophages in HIV pathogenesis. Additionally, we will review the role of monocytes and macrophages in the development of serious non-AIDS events including cardiovascular disease and neurocognitive impairment, their significance in viral persistence, and how these cells represent an important obstacle to achieving HIV eradication.

Original languageEnglish
Pages (from-to)2175-2187
Number of pages13
JournalAIDS
Volume28
Issue number15
DOIs
Publication statusPublished - 24 Sep 2014

Keywords

  • HIV cure
  • HIV pathogenesis
  • Macrophage
  • Monocyte
  • Reservoirs

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