TY - JOUR
T1 - The impact of time between staging PET/CT and definitive chemo-radiation on target volumes and survival in patients with non-small cell lung cancer
AU - Everitt, Sarah Jane
AU - Plumridge, Nikki
AU - Herschtal, Alan
AU - Bressel, Matias
AU - Ball, David
AU - Callahan, Jason W
AU - Kron, Tomas
AU - Schneider-Kolsky, Michal Elisabeth
AU - Binns, David
AU - Hicks, Rodney
AU - MacManus, Michael
PY - 2013
Y1 - 2013
N2 - BACKGROUND AND PURPOSE: To investigate the impact of treatment delays on radiation therapy (RT) target volumes and overall survival (OS) in patients with non-small cell lung cancer (NSCLC) who underwent two baseline FDG PET/CT scans. MATERIAL AND METHODS: Patients underwent a staging (PET1) and RT planning (PET2) FDG PET/CT scan. At PET1 all patients were eligible for radical chemo-RT. OS and progression-free survival (PFS) were compared for patients remaining eligible for radical RT and those treated palliatively because PET2 showed progression. RT target volumes were contoured using PET1 and PET2. Normal tissue doses were compared for patients remaining eligible for radical RT. RESULTS: Eighty-two patients underwent PET2 scans between October 2004 and February 2007. Of these, 21 had a prior PET1 scan, median 23days apart (range 8-176days). Six patients (29 ) were unsuitable for radical RT after PET2; five received palliative treatment and one received no treatment. Patients treated palliatively had significantly worse OS and PFS than patients treated radically p
AB - BACKGROUND AND PURPOSE: To investigate the impact of treatment delays on radiation therapy (RT) target volumes and overall survival (OS) in patients with non-small cell lung cancer (NSCLC) who underwent two baseline FDG PET/CT scans. MATERIAL AND METHODS: Patients underwent a staging (PET1) and RT planning (PET2) FDG PET/CT scan. At PET1 all patients were eligible for radical chemo-RT. OS and progression-free survival (PFS) were compared for patients remaining eligible for radical RT and those treated palliatively because PET2 showed progression. RT target volumes were contoured using PET1 and PET2. Normal tissue doses were compared for patients remaining eligible for radical RT. RESULTS: Eighty-two patients underwent PET2 scans between October 2004 and February 2007. Of these, 21 had a prior PET1 scan, median 23days apart (range 8-176days). Six patients (29 ) were unsuitable for radical RT after PET2; five received palliative treatment and one received no treatment. Patients treated palliatively had significantly worse OS and PFS than patients treated radically p
UR - http://goo.gl/86OgUV
UR - https://www.scopus.com/pages/publications/84876134084
U2 - 10.1016/j.radonc.2013.02.010
DO - 10.1016/j.radonc.2013.02.010
M3 - Article
SN - 0167-8140
VL - 106
SP - 288
EP - 291
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 3
ER -
