The impact of sleep disordered breathing on cardiovascular health in overweight children

Rosemary SC Horne, Genevieve Shandler, Knarik Tamanyan, Aidan J Weichard, Alexsandria Odoi, Sarah Nichole Biggs, Margot Davey, Gillian Michelle Nixon, Lisa Mary Walter

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Background Up to 50% of overweight/obese children have obstructive sleep apnea (OSA) compared to up to 6% of normal weight children. We compared cardiovascular variables between normal weight and overweight/obese children with and without OSA, and controls. Methods Seventy-four referred children and 24 normal weight non-snoring controls (8–18 years) were recruited. Referred children were grouped according to their obstructive apnea hypopnea index (OAHI): OSA (>1 event/h) or primary snoring (PS ≤ 1 event/h) and whether they were normal weight (BMI z-score <1.04) or overweight/obese (BMI z-score ≥ 1.04). Wake blood pressure (BP), heart rate (HR), and pulse transit time (PTT, an inverse continuous surrogate measure of blood pressure) during sleep were recorded. Results Wake BP was higher in the overweight/obese OSA group than in the control, normal weight PS, and overweight/obese PS groups (p < 0.05 for all). During sleep, BP, and HR were elevated in the overweight/obese OSA group compared to those in non-snoring controls (p < 0.05). More children who were overweight/obese had reduced BP and HR dipping from wake to sleep than normal weight children. The BMI z-score predicted HR and PTT when asleep and both age and BMI z-score predicted BP when awake. Conclusion This study showed that BMI has both combined and independent effects on BP and HR in children with OSA. We have previously shown that treatment of OSA reduces BP and suggest that treatment of OSA in the growing number of overweight/obese children may improve cardiovascular outcomes.
Original languageEnglish
Pages (from-to)58-68
Number of pages11
JournalSleep Medicine
Volume41
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Blood pressure
  • Heart rate
  • Heart rate variability
  • Nocturnal dipping
  • Pediatric
  • Sleep

Cite this

Horne, Rosemary SC ; Shandler, Genevieve ; Tamanyan, Knarik ; Weichard, Aidan J ; Odoi, Alexsandria ; Biggs, Sarah Nichole ; Davey, Margot ; Nixon, Gillian Michelle ; Walter, Lisa Mary. / The impact of sleep disordered breathing on cardiovascular health in overweight children. In: Sleep Medicine. 2018 ; Vol. 41. pp. 58-68.
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abstract = "Background Up to 50{\%} of overweight/obese children have obstructive sleep apnea (OSA) compared to up to 6{\%} of normal weight children. We compared cardiovascular variables between normal weight and overweight/obese children with and without OSA, and controls. Methods Seventy-four referred children and 24 normal weight non-snoring controls (8–18 years) were recruited. Referred children were grouped according to their obstructive apnea hypopnea index (OAHI): OSA (>1 event/h) or primary snoring (PS ≤ 1 event/h) and whether they were normal weight (BMI z-score <1.04) or overweight/obese (BMI z-score ≥ 1.04). Wake blood pressure (BP), heart rate (HR), and pulse transit time (PTT, an inverse continuous surrogate measure of blood pressure) during sleep were recorded. Results Wake BP was higher in the overweight/obese OSA group than in the control, normal weight PS, and overweight/obese PS groups (p < 0.05 for all). During sleep, BP, and HR were elevated in the overweight/obese OSA group compared to those in non-snoring controls (p < 0.05). More children who were overweight/obese had reduced BP and HR dipping from wake to sleep than normal weight children. The BMI z-score predicted HR and PTT when asleep and both age and BMI z-score predicted BP when awake. Conclusion This study showed that BMI has both combined and independent effects on BP and HR in children with OSA. We have previously shown that treatment of OSA reduces BP and suggest that treatment of OSA in the growing number of overweight/obese children may improve cardiovascular outcomes.",
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The impact of sleep disordered breathing on cardiovascular health in overweight children. / Horne, Rosemary SC; Shandler, Genevieve; Tamanyan, Knarik; Weichard, Aidan J; Odoi, Alexsandria; Biggs, Sarah Nichole; Davey, Margot; Nixon, Gillian Michelle; Walter, Lisa Mary.

In: Sleep Medicine, Vol. 41, 01.01.2018, p. 58-68.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The impact of sleep disordered breathing on cardiovascular health in overweight children

AU - Horne, Rosemary SC

AU - Shandler, Genevieve

AU - Tamanyan, Knarik

AU - Weichard, Aidan J

AU - Odoi, Alexsandria

AU - Biggs, Sarah Nichole

AU - Davey, Margot

AU - Nixon, Gillian Michelle

AU - Walter, Lisa Mary

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background Up to 50% of overweight/obese children have obstructive sleep apnea (OSA) compared to up to 6% of normal weight children. We compared cardiovascular variables between normal weight and overweight/obese children with and without OSA, and controls. Methods Seventy-four referred children and 24 normal weight non-snoring controls (8–18 years) were recruited. Referred children were grouped according to their obstructive apnea hypopnea index (OAHI): OSA (>1 event/h) or primary snoring (PS ≤ 1 event/h) and whether they were normal weight (BMI z-score <1.04) or overweight/obese (BMI z-score ≥ 1.04). Wake blood pressure (BP), heart rate (HR), and pulse transit time (PTT, an inverse continuous surrogate measure of blood pressure) during sleep were recorded. Results Wake BP was higher in the overweight/obese OSA group than in the control, normal weight PS, and overweight/obese PS groups (p < 0.05 for all). During sleep, BP, and HR were elevated in the overweight/obese OSA group compared to those in non-snoring controls (p < 0.05). More children who were overweight/obese had reduced BP and HR dipping from wake to sleep than normal weight children. The BMI z-score predicted HR and PTT when asleep and both age and BMI z-score predicted BP when awake. Conclusion This study showed that BMI has both combined and independent effects on BP and HR in children with OSA. We have previously shown that treatment of OSA reduces BP and suggest that treatment of OSA in the growing number of overweight/obese children may improve cardiovascular outcomes.

AB - Background Up to 50% of overweight/obese children have obstructive sleep apnea (OSA) compared to up to 6% of normal weight children. We compared cardiovascular variables between normal weight and overweight/obese children with and without OSA, and controls. Methods Seventy-four referred children and 24 normal weight non-snoring controls (8–18 years) were recruited. Referred children were grouped according to their obstructive apnea hypopnea index (OAHI): OSA (>1 event/h) or primary snoring (PS ≤ 1 event/h) and whether they were normal weight (BMI z-score <1.04) or overweight/obese (BMI z-score ≥ 1.04). Wake blood pressure (BP), heart rate (HR), and pulse transit time (PTT, an inverse continuous surrogate measure of blood pressure) during sleep were recorded. Results Wake BP was higher in the overweight/obese OSA group than in the control, normal weight PS, and overweight/obese PS groups (p < 0.05 for all). During sleep, BP, and HR were elevated in the overweight/obese OSA group compared to those in non-snoring controls (p < 0.05). More children who were overweight/obese had reduced BP and HR dipping from wake to sleep than normal weight children. The BMI z-score predicted HR and PTT when asleep and both age and BMI z-score predicted BP when awake. Conclusion This study showed that BMI has both combined and independent effects on BP and HR in children with OSA. We have previously shown that treatment of OSA reduces BP and suggest that treatment of OSA in the growing number of overweight/obese children may improve cardiovascular outcomes.

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KW - Heart rate variability

KW - Nocturnal dipping

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U2 - 10.1016/j.sleep.2017.09.012

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