The impact of saturable metabolism on exposure-response relations in 2 studies of benzene-induced leukemia

Jelle Vlaanderen, Lutzen Portengen, Stephen Rappaport, Deborah Glass, Hans Kromhout, Roel Vermeulen

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)


Enzymatic saturation of metabolic pathways is one factor that potentially contributes to the nonlinear exposure-response relations that are frequently reported in occupational epidemiologic studies. The authors propose an approach to explore the contribution of saturable metabolism to previously reported exposure-response relations by integrating predictive models of relevant biomarkers of exposure into the epidemiologic analysis.
Original languageEnglish
Pages (from-to)621 - 629
Number of pages9
JournalAmerican Journal of Epidemiology
Issue number5
Publication statusPublished - 2011

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