The impact of oculomotor functioning on neuropsychological performance in Huntington disease

Janessa O. Carvalho; Jeffrey D Long; Holly J. Westervelt; Megan M. Smith; Jared M. Bruce; Ji In Kim; James A. Mills; Jane S Paulsen; Isabella De Soriano; Courtney Shadrick; Amanda Miller; Edmond Chiu; Joy Preston; Anita Goh; Stephanie Antonopoulos; Samantha Loi; Phyllis Chua; Angela Komiti; Lynn Raymond; Joji Decolongon; Mannie Fan; Allison Coleman; Christopher A. Ross; Mark Varvaris; Maryjane Ong; Nadine Yoritomo; William M. Mallonee; Greg Suter; Ali Samii; Emily P. Freney; Alma Macaraeg; Rebecca Jones; Cathy Wood-Siverio; Stewart A. Factor; Roger A Barker; Sarah Mason; Natalie Valle Guzman; Elizabeth McCusker; Jane F Griffith; Clement Loy; Jillian McMillan; David Gunn; Michael Orth; Sigurd Süßmuth; Katrin Barth; Sonja Trautmann; Daniela Schwenk; Carolin Eschenbach; Kimberly Quaid; Melissa Wesson; Joanne Wojcieszek; Mark Guttman; Alanna Sheinberg; Albie Law; Irita Karmalkar; Susan L Perlman; Brian Clemente; Michael D. Geschwind; Sharon Sha; Joseph Winer; Gabriela Satris; Tom Warner; Maggie Burrows; Anne Rosser; Kathy Price; Sarah Hunt; Frederick Marshall; Amy Chesire; Mary Wodarski; Charlyne Hickey; Peter K Panegyres; Joseph Lee; Maria Tedesco; Brenton Maxwell; Joel Perlmutter; Stacey Barton; Shineeka Smith; Zosia Miedzybrodzka; Daniela Rae; Vivien Vaughan; Mariella D'Alessandro; David O Craufurd; Judith Bek; Elizabeth Howard; Pietro Mazzoni; Karen S Marder; Paula Wasserman; Rajeev Kumar; Diane Erickson; Christina Reeves; Breanna Nickels; Vicki Wheelock; Lisa Kjer; Amanda Martin; Sarah Farias; Wayne Martin; Oksana Suchowersky; Pamela King; Marguerite Wieler; Satwinder Sran; Anwar Ahmed; Stephen Rao; Christine Reece; Alex Bura; Lyla Mourany; Phil Danzer; Kelsey Montross; Deborah Harrington; Holly Westervalt; Elizabeth Hoppes Aylward; David J Moser; Janet Williams; Nancy Downing; Vincent A. Magnotta; Hans J. Johnson; Thomas Brashers-Krug; Jatin Vaidya; Daniel O'Leary; Eun Young Kim; Spencer G Lourens; Ying Zhang; Wenjing Lu; Cheryl Erwin; Martha Nance; Henry Jeremy Bockholt; Jason Evans; Roland Zschiegner; the PREDICT-HD Investigators and Coordinators of the Huntington Study Group

doi:10.1080/13803395.2015.1101054

The impact of oculomotor functioning on neuropsychological performance in Huntington disease

Janessa O. Carvalho, Jeffrey D Long, Holly J. Westervelt, Megan M. Smith, Jared M. Bruce, Ji In Kim, James A. Mills, Jane S Paulsen, Isabella De Soriano, Courtney Shadrick, Amanda Miller, Edmond Chiu, Joy Preston, Anita Goh, Stephanie Antonopoulos, Samantha Loi, Phyllis Chua, Angela Komiti, Lynn Raymond, Joji DecolongonMannie Fan, Allison Coleman, Christopher A. Ross, Mark Varvaris, Maryjane Ong, Nadine Yoritomo, William M. Mallonee, Greg Suter, Ali Samii, Emily P. Freney, Alma Macaraeg, Rebecca Jones, Cathy Wood-Siverio, Stewart A. Factor, Roger A Barker, Sarah Mason, Natalie Valle Guzman, Elizabeth McCusker, Jane F Griffith, Clement Loy, Jillian McMillan, David Gunn, Michael Orth, Sigurd Süßmuth, Katrin Barth, Sonja Trautmann, Daniela Schwenk, Carolin Eschenbach, Kimberly Quaid, Melissa Wesson, Joanne Wojcieszek, Mark Guttman, Alanna Sheinberg, Albie Law, Irita Karmalkar, Susan L Perlman, Brian Clemente, Michael D. Geschwind, Sharon Sha, Joseph Winer, Gabriela Satris, Tom Warner, Maggie Burrows, Anne Rosser, Kathy Price, Sarah Hunt, Frederick Marshall, Amy Chesire, Mary Wodarski, Charlyne Hickey, Peter K Panegyres, Joseph Lee, Maria Tedesco, Brenton Maxwell, Joel Perlmutter, Stacey Barton, Shineeka Smith, Zosia Miedzybrodzka, Daniela Rae, Vivien Vaughan, Mariella D'Alessandro, David O Craufurd, Judith Bek, Elizabeth Howard, Pietro Mazzoni, Karen S Marder, Paula Wasserman, Rajeev Kumar, Diane Erickson, Christina Reeves, Breanna Nickels, Vicki Wheelock, Lisa Kjer, Amanda Martin, Sarah Farias, Wayne Martin, Oksana Suchowersky, Pamela King, Marguerite Wieler, Satwinder Sran, Anwar Ahmed, Stephen Rao, Christine Reece, Alex Bura, Lyla Mourany, Phil Danzer, Kelsey Montross, Deborah Harrington, Holly Westervalt, Elizabeth Hoppes Aylward, David J Moser, Janet Williams, Nancy Downing, Vincent A. Magnotta, Hans J. Johnson, Thomas Brashers-Krug, Jatin Vaidya, Daniel O'Leary, Eun Young Kim, Spencer G Lourens, Ying Zhang, Wenjing Lu, Cheryl Erwin, Martha Nance, Henry Jeremy Bockholt, Jason Evans, Roland Zschiegner, the PREDICT-HD Investigators and Coordinators of the Huntington Study Group

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.

Original language	English
Pages (from-to)	217-226
Number of pages	10
Journal	Journal of Clinical and Experimental Neuropsychology
Volume	38
Issue number	2
DOIs	https://doi.org/10.1080/13803395.2015.1101054
Publication status	Published - 7 Feb 2016
Externally published	Yes

Keywords

Huntington disease
Neuropsychology
Oculomotor functioning
PREDICT-HD
Processing speed

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10.1080/13803395.2015.1101054

Cite this

Carvalho, J. O., Long, J. D., Westervelt, H. J., Smith, M. M., Bruce, J. M., Kim, J. I., Mills, J. A., Paulsen, J. S., De Soriano, I., Shadrick, C., Miller, A., Chiu, E., Preston, J., Goh, A., Antonopoulos, S., Loi, S., Chua, P., Komiti, A., Raymond, L., ... the PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2016). The impact of oculomotor functioning on neuropsychological performance in Huntington disease. Journal of Clinical and Experimental Neuropsychology, 38(2), 217-226. https://doi.org/10.1080/13803395.2015.1101054

@article{51b838aa3de94cb2ba15287ee6a5f93d,

title = "The impact of oculomotor functioning on neuropsychological performance in Huntington disease",

abstract = "Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.",

keywords = "Huntington disease, Neuropsychology, Oculomotor functioning, PREDICT-HD, Processing speed",

author = "Carvalho, {Janessa O.} and Long, {Jeffrey D} and Westervelt, {Holly J.} and Smith, {Megan M.} and Bruce, {Jared M.} and Kim, {Ji In} and Mills, {James A.} and Paulsen, {Jane S} and {De Soriano}, Isabella and Courtney Shadrick and Amanda Miller and Edmond Chiu and Joy Preston and Anita Goh and Stephanie Antonopoulos and Samantha Loi and Phyllis Chua and Angela Komiti and Lynn Raymond and Joji Decolongon and Mannie Fan and Allison Coleman and Ross, {Christopher A.} and Mark Varvaris and Maryjane Ong and Nadine Yoritomo and Mallonee, {William M.} and Greg Suter and Ali Samii and Freney, {Emily P.} and Alma Macaraeg and Rebecca Jones and Cathy Wood-Siverio and Factor, {Stewart A.} and Barker, {Roger A} and Sarah Mason and Guzman, {Natalie Valle} and Elizabeth McCusker and Griffith, {Jane F} and Clement Loy and Jillian McMillan and David Gunn and Michael Orth and Sigurd S{\"u}{\ss}muth and Katrin Barth and Sonja Trautmann and Daniela Schwenk and Carolin Eschenbach and Kimberly Quaid and Melissa Wesson and Joanne Wojcieszek and Mark Guttman and Alanna Sheinberg and Albie Law and Irita Karmalkar and Perlman, {Susan L} and Brian Clemente and Geschwind, {Michael D.} and Sharon Sha and Joseph Winer and Gabriela Satris and Tom Warner and Maggie Burrows and Anne Rosser and Kathy Price and Sarah Hunt and Frederick Marshall and Amy Chesire and Mary Wodarski and Charlyne Hickey and Panegyres, {Peter K} and Joseph Lee and Maria Tedesco and Brenton Maxwell and Joel Perlmutter and Stacey Barton and Shineeka Smith and Zosia Miedzybrodzka and Daniela Rae and Vivien Vaughan and Mariella D'Alessandro and Craufurd, {David O} and Judith Bek and Elizabeth Howard and Pietro Mazzoni and Marder, {Karen S} and Paula Wasserman and Rajeev Kumar and Diane Erickson and Christina Reeves and Breanna Nickels and Vicki Wheelock and Lisa Kjer and Amanda Martin and Sarah Farias and Wayne Martin and Oksana Suchowersky and Pamela King and Marguerite Wieler and Satwinder Sran and Anwar Ahmed and Stephen Rao and Christine Reece and Alex Bura and Lyla Mourany and Phil Danzer and Kelsey Montross and Deborah Harrington and Holly Westervalt and Aylward, {Elizabeth Hoppes} and Moser, {David J} and Janet Williams and Nancy Downing and Magnotta, {Vincent A.} and Johnson, {Hans J.} and Thomas Brashers-Krug and Jatin Vaidya and Daniel O'Leary and {Young Kim}, Eun and Lourens, {Spencer G} and Ying Zhang and Wenjing Lu and Cheryl Erwin and Martha Nance and Bockholt, {Henry Jeremy} and Jason Evans and Roland Zschiegner and {the PREDICT-HD Investigators and Coordinators of the Huntington Study Group}",

year = "2016",

month = feb,

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doi = "10.1080/13803395.2015.1101054",

language = "English",

volume = "38",

pages = "217--226",

journal = "Journal of Clinical and Experimental Neuropsychology",

issn = "1380-3395",

publisher = "Taylor & Francis",

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Carvalho, JO, Long, JD, Westervelt, HJ, Smith, MM, Bruce, JM, Kim, JI, Mills, JA, Paulsen, JS, De Soriano, I, Shadrick, C, Miller, A, Chiu, E, Preston, J, Goh, A, Antonopoulos, S, Loi, S, Chua, P, Komiti, A, Raymond, L, Decolongon, J, Fan, M, Coleman, A, Ross, CA, Varvaris, M, Ong, M, Yoritomo, N, Mallonee, WM, Suter, G, Samii, A, Freney, EP, Macaraeg, A, Jones, R, Wood-Siverio, C, Factor, SA, Barker, RA, Mason, S, Guzman, NV, McCusker, E, Griffith, JF, Loy, C, McMillan, J, Gunn, D, Orth, M, Süßmuth, S, Barth, K, Trautmann, S, Schwenk, D, Eschenbach, C, Quaid, K, Wesson, M, Wojcieszek, J, Guttman, M, Sheinberg, A, Law, A, Karmalkar, I, Perlman, SL, Clemente, B, Geschwind, MD, Sha, S, Winer, J, Satris, G, Warner, T, Burrows, M, Rosser, A, Price, K, Hunt, S, Marshall, F, Chesire, A, Wodarski, M, Hickey, C, Panegyres, PK, Lee, J, Tedesco, M, Maxwell, B, Perlmutter, J, Barton, S, Smith, S, Miedzybrodzka, Z, Rae, D, Vaughan, V, D'Alessandro, M, Craufurd, DO, Bek, J, Howard, E, Mazzoni, P, Marder, KS, Wasserman, P, Kumar, R, Erickson, D, Reeves, C, Nickels, B, Wheelock, V, Kjer, L, Martin, A, Farias, S, Martin, W, Suchowersky, O, King, P, Wieler, M, Sran, S, Ahmed, A, Rao, S, Reece, C, Bura, A, Mourany, L, Danzer, P, Montross, K, Harrington, D, Westervalt, H, Aylward, EH, Moser, DJ, Williams, J, Downing, N, Magnotta, VA, Johnson, HJ, Brashers-Krug, T, Vaidya, J, O'Leary, D, Young Kim, E, Lourens, SG, Zhang, Y, Lu, W, Erwin, C, Nance, M, Bockholt, HJ, Evans, J, Zschiegner, R & the PREDICT-HD Investigators and Coordinators of the Huntington Study Group 2016, 'The impact of oculomotor functioning on neuropsychological performance in Huntington disease', Journal of Clinical and Experimental Neuropsychology, vol. 38, no. 2, pp. 217-226. https://doi.org/10.1080/13803395.2015.1101054

TY - JOUR

T1 - The impact of oculomotor functioning on neuropsychological performance in Huntington disease

AU - Carvalho, Janessa O.

AU - Long, Jeffrey D

AU - Westervelt, Holly J.

AU - Smith, Megan M.

AU - Bruce, Jared M.

AU - Kim, Ji In

AU - Mills, James A.

AU - Paulsen, Jane S

AU - De Soriano, Isabella

AU - Shadrick, Courtney

AU - Miller, Amanda

AU - Chiu, Edmond

AU - Preston, Joy

AU - Goh, Anita

AU - Antonopoulos, Stephanie

AU - Loi, Samantha

AU - Chua, Phyllis

AU - Komiti, Angela

AU - Raymond, Lynn

AU - Decolongon, Joji

AU - Fan, Mannie

AU - Coleman, Allison

AU - Ross, Christopher A.

AU - Varvaris, Mark

AU - Ong, Maryjane

AU - Yoritomo, Nadine

AU - Mallonee, William M.

AU - Suter, Greg

AU - Samii, Ali

AU - Freney, Emily P.

AU - Macaraeg, Alma

AU - Jones, Rebecca

AU - Wood-Siverio, Cathy

AU - Factor, Stewart A.

AU - Barker, Roger A

AU - Mason, Sarah

AU - Guzman, Natalie Valle

AU - McCusker, Elizabeth

AU - Griffith, Jane F

AU - Loy, Clement

AU - McMillan, Jillian

AU - Gunn, David

AU - Orth, Michael

AU - Süßmuth, Sigurd

AU - Barth, Katrin

AU - Trautmann, Sonja

AU - Schwenk, Daniela

AU - Eschenbach, Carolin

AU - Quaid, Kimberly

AU - Wesson, Melissa

AU - Wojcieszek, Joanne

AU - Guttman, Mark

AU - Sheinberg, Alanna

AU - Law, Albie

AU - Karmalkar, Irita

AU - Perlman, Susan L

AU - Clemente, Brian

AU - Geschwind, Michael D.

AU - Sha, Sharon

AU - Winer, Joseph

AU - Satris, Gabriela

AU - Warner, Tom

AU - Burrows, Maggie

AU - Rosser, Anne

AU - Price, Kathy

AU - Hunt, Sarah

AU - Marshall, Frederick

AU - Chesire, Amy

AU - Wodarski, Mary

AU - Hickey, Charlyne

AU - Panegyres, Peter K

AU - Lee, Joseph

AU - Tedesco, Maria

AU - Maxwell, Brenton

AU - Perlmutter, Joel

AU - Barton, Stacey

AU - Smith, Shineeka

AU - Miedzybrodzka, Zosia

AU - Rae, Daniela

AU - Vaughan, Vivien

AU - D'Alessandro, Mariella

AU - Craufurd, David O

AU - Bek, Judith

AU - Howard, Elizabeth

AU - Mazzoni, Pietro

AU - Marder, Karen S

AU - Wasserman, Paula

AU - Kumar, Rajeev

AU - Erickson, Diane

AU - Reeves, Christina

AU - Nickels, Breanna

AU - Wheelock, Vicki

AU - Kjer, Lisa

AU - Martin, Amanda

AU - Farias, Sarah

AU - Martin, Wayne

AU - Suchowersky, Oksana

AU - King, Pamela

AU - Wieler, Marguerite

AU - Sran, Satwinder

AU - Ahmed, Anwar

AU - Rao, Stephen

AU - Reece, Christine

AU - Bura, Alex

AU - Mourany, Lyla

AU - Danzer, Phil

AU - Montross, Kelsey

AU - Harrington, Deborah

AU - Westervalt, Holly

AU - Aylward, Elizabeth Hoppes

AU - Moser, David J

AU - Williams, Janet

AU - Downing, Nancy

AU - Magnotta, Vincent A.

AU - Johnson, Hans J.

AU - Brashers-Krug, Thomas

AU - Vaidya, Jatin

AU - O'Leary, Daniel

AU - Young Kim, Eun

AU - Lourens, Spencer G

AU - Zhang, Ying

AU - Lu, Wenjing

AU - Erwin, Cheryl

AU - Nance, Martha

AU - Bockholt, Henry Jeremy

AU - Evans, Jason

AU - Zschiegner, Roland

AU - the PREDICT-HD Investigators and Coordinators of the Huntington Study Group

PY - 2016/2/7

Y1 - 2016/2/7

N2 - Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.

AB - Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.

KW - Huntington disease

KW - Neuropsychology

KW - Oculomotor functioning

KW - PREDICT-HD

KW - Processing speed

UR - http://www.scopus.com/inward/record.url?scp=84954062766&partnerID=8YFLogxK

U2 - 10.1080/13803395.2015.1101054

DO - 10.1080/13803395.2015.1101054

M3 - Article

C2 - 26745770

AN - SCOPUS:84954062766

SN - 1380-3395

VL - 38

SP - 217

EP - 226

JO - Journal of Clinical and Experimental Neuropsychology

JF - Journal of Clinical and Experimental Neuropsychology

IS - 2

ER -

The impact of oculomotor functioning on neuropsychological performance in Huntington disease

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Keywords

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