The impact of obesity on oocytes: Evidence for lipotoxicity mechanisms

Linda L.Y. Wu; Robert J. Norman; Rebecca L. Robker

doi:10.1071/RD11904

The impact of obesity on oocytes: Evidence for lipotoxicity mechanisms

Linda L.Y. Wu, Robert J. Norman, Rebecca L. Robker

Anatomy & Developmental Biology

Research output: Contribution to journal › Review Article › Research › peer-review

78 Citations (Scopus)

Abstract

Obesity can have detrimental effects on pregnancy rates in natural conceptions and also in women undergoing IVF or intracytoplasmic sperm injection (ICSI). This review summarises the most recent clinical literature investigating whether obesity impacts oocyte quality and early embryo growth. In other tissues, obesity leads to lipotoxicity responses including endoplasmic reticulum stress, mitochondrial dysfunction and apoptosis. Recent reports indicate that lipotoxicity is a mechanism by which obesity may impact oocyte quality.

Original language	English
Pages (from-to)	29-34
Number of pages	6
Journal	Reproduction, Fertility and Development
Volume	24
Issue number	1
DOIs	https://doi.org/10.1071/RD11904
Publication status	Published - 1 Jan 2012

Keywords

endoplasmic reticulum stress
palmitate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1071/RD11904

Cite this

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The impact of obesity on oocytes: Evidence for lipotoxicity mechanisms

Abstract

Keywords

UN SDGs

Access to Document

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