TY - JOUR
T1 - The impact of molecular weight and PEG chain length on the systemic pharmacokinetics of pegylated poly L-lysine dendrimers
AU - Kaminskas, Lisa Michelle
AU - Boyd, Benjamin James
AU - Karellas, Peter
AU - Krippner, Guy Yeoman
AU - Lessene, Romina
AU - Kelly, Brian
AU - Porter, Christopher John
PY - 2008
Y1 - 2008
N2 - The impact of PEGylation on the pharmacokinetics and biodistribution of 3H-labeled poly L-lysine dendrimers has been investrigated after intravenous administration to rats. The volumes of distribtuion, clearance and consequentrly the plasma half-lives of the PEGylated dendirmers were markedly dependent ont he total molecular weight of the PEGylated dendirmer, but were not specifically affectd byt eh PEG chain lenght alone. In general, the larger dendrimer constructs (i.e. >30KDa)had reduced volumes of distribtuion, were poorly renally cleared and exhibited extended elimination half-lives (t1/2 1-3 days) when compared to the smaller dendrimers (i.e.
AB - The impact of PEGylation on the pharmacokinetics and biodistribution of 3H-labeled poly L-lysine dendrimers has been investrigated after intravenous administration to rats. The volumes of distribtuion, clearance and consequentrly the plasma half-lives of the PEGylated dendirmers were markedly dependent ont he total molecular weight of the PEGylated dendirmer, but were not specifically affectd byt eh PEG chain lenght alone. In general, the larger dendrimer constructs (i.e. >30KDa)had reduced volumes of distribtuion, were poorly renally cleared and exhibited extended elimination half-lives (t1/2 1-3 days) when compared to the smaller dendrimers (i.e.
M3 - Article
VL - 5
SP - 449
EP - 463
JO - Molecular Pharmaceutics
JF - Molecular Pharmaceutics
SN - 1543-8384
IS - 3
ER -