TY - JOUR
T1 - The impact of intensified exercise training on insulin resistance and fitness in overweight and obese women with and without polycystic ovary syndrome
AU - Harrison, Cheryce
AU - Stepto, Nigel
AU - Hutchison, Samantha
AU - Teede, Helena
PY - 2012
Y1 - 2012
N2 - Objective
To evaluate mechanisms of insulin resistance (IR) in overweight and obese women with and without PCOS and explore relationships between IR, fitness and body mass index (BMI) at baseline and following exercise intervention.
Design
Prospective controlled intensified exercise intervention study.
Conclusions
While intensified exercise improves insulin resistance in PCOS women, a higher IR persisted following exercise in PCOS women and a clear relationship between improved IR and improved fitness was not found. Therefore, other mechanisms of, and therapies for, IR must be explored in PCOS as IR remains higher than observed in non-PCOS controls.
AB - Objective
To evaluate mechanisms of insulin resistance (IR) in overweight and obese women with and without PCOS and explore relationships between IR, fitness and body mass index (BMI) at baseline and following exercise intervention.
Design
Prospective controlled intensified exercise intervention study.
Conclusions
While intensified exercise improves insulin resistance in PCOS women, a higher IR persisted following exercise in PCOS women and a clear relationship between improved IR and improved fitness was not found. Therefore, other mechanisms of, and therapies for, IR must be explored in PCOS as IR remains higher than observed in non-PCOS controls.
UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2011.04160.x/abstract
U2 - 10.1111/j.1365-2265.2011.04160.x
DO - 10.1111/j.1365-2265.2011.04160.x
M3 - Article
VL - 76
SP - 351
EP - 357
JO - Clinical Endocrinology
JF - Clinical Endocrinology
SN - 0300-0664
IS - 3
ER -