The impact of chronic disease on response to infection

M. C. Reade, E. B. Milbrandt, D. C. Angus

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)


Most patients with sepsis have underlying co-morbidities. Co-existing disease is typically thought to influence the pathophysiology and outcome of sepsis by reducing physiological reserve. Certainly this is true: A patient with chronic obstructive pulmonary disease (COPD) will tolerate pneumonia less well than a patient with previously healthy lungs. Additionally, many chronic disease states (or their treatments) alter the pre-existing inflammatory and immune milieu. This effect ranges from the obvious (as in the case of patients taking immunosuppressant therapy) to the under-appreciated (as in the inflammatory dysregulation associated with obesity). In seeking explanations for differences in the host response to infection, much has been made of the possible effects of genetic variability. However, subtle variations in the underlying state of the immune and inflammatory systems have received little attention.

Original languageEnglish
Title of host publicationIntensive Care Medicine
Subtitle of host publicationAnnual Update 2007
Number of pages11
ISBN (Print)0387495177, 9780387495170
Publication statusPublished - 1 Dec 2007

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