TY - JOUR
T1 - The impact of age at onset of bipolar I disorder on functioning and clinical presentation
AU - Biffin, Frances Elizabeth
AU - Tahtalian, Stavros Steven
AU - Filia, Kate M
AU - Fitzgerald, Paul Bernard
AU - De Castella, Rolet Anthony
AU - Filia, Sacha Louise
AU - Berk, Michael
AU - Dodd, Seetal
AU - Callaly, Pam
AU - Berk, Lesley A
AU - Kelin, Katarina
AU - Smith, Meg M
AU - Montgomery, William
AU - Kulkarni, Jayashri
PY - 2009
Y1 - 2009
N2 - Objectives: Recent studies have proposed the existence of three distinct subgroups of bipolar 1 disorder based on age at onset (AAO). The present study aims to investigate potential clinical and functional differences between these subgroups in an Australian sample. Methods: Participants (n = 239) were enrolled in the Bipolar Comprehensive Outcomes Study (BCOS), a 2-year longitudinal, observational, cross-sectional study. Assessment measures included the Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HAMD21), Clinical Global Impressions Scale (CGI-BP), SF-36, SLICE/Life Scale, and the EuroQol (EQ-5D). Participants were also asked about their age at the first major affective episode. Results: Three AAO groups were compared: early (AAO <20, mean = 15.5 ? 2.72; 44.4 of the participants); intermediate (AAO 20-39, mean = 26.1 ? 4.8; 48.14 of the participants) and late (AAO > 40, mean = 50.6 ? 9.04; 7.4 of the participants). Higher rates of depression, suicidal ideation and binge drinking were reported by the early AAO group. This group also reported poorer quality of life in a number of areas. The early AAO group had a predominant depressive initial polarity and the intermediate group had a manic predominance. Conclusion: Early AAO is associated with an adverse outcome. ? 2009 John Wiley Sons A/S.
AB - Objectives: Recent studies have proposed the existence of three distinct subgroups of bipolar 1 disorder based on age at onset (AAO). The present study aims to investigate potential clinical and functional differences between these subgroups in an Australian sample. Methods: Participants (n = 239) were enrolled in the Bipolar Comprehensive Outcomes Study (BCOS), a 2-year longitudinal, observational, cross-sectional study. Assessment measures included the Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HAMD21), Clinical Global Impressions Scale (CGI-BP), SF-36, SLICE/Life Scale, and the EuroQol (EQ-5D). Participants were also asked about their age at the first major affective episode. Results: Three AAO groups were compared: early (AAO <20, mean = 15.5 ? 2.72; 44.4 of the participants); intermediate (AAO 20-39, mean = 26.1 ? 4.8; 48.14 of the participants) and late (AAO > 40, mean = 50.6 ? 9.04; 7.4 of the participants). Higher rates of depression, suicidal ideation and binge drinking were reported by the early AAO group. This group also reported poorer quality of life in a number of areas. The early AAO group had a predominant depressive initial polarity and the intermediate group had a manic predominance. Conclusion: Early AAO is associated with an adverse outcome. ? 2009 John Wiley Sons A/S.
UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1601-5215.2009.00399.x/pdf
U2 - 10.1111/j.1601-5215.2009.00399.x
DO - 10.1111/j.1601-5215.2009.00399.x
M3 - Article
VL - 21
SP - 191
EP - 196
JO - Acta Neuropsychiatrica
JF - Acta Neuropsychiatrica
SN - 0924-2708
IS - 4
ER -
