The immunomodulating role of exercise in metabolic disease

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A lack of physical activity is linked to the development of many chronic diseases. It is now well established that the immune system and inflammation play a central role in the development of numerous chronic metabolic diseases including insulin resistance, type 2 diabetes, atherosclerosis, nonalcoholic fatty liver disease, and specific types of cancer. Physical exercise elicits potent anti-inflammatory effects that are likely to account for many of the salutary actions of regular exercise on chronic metabolic diseases. Here we review the anti-inflammatory and immunomodulatory mechanisms by which the beneficial effects of exercise on chronic metabolic diseases may be mediated.

Original languageEnglish
Pages (from-to)262-269
Number of pages8
JournalTrends in Immunology
Issue number6
Publication statusPublished - Jun 2014
Externally publishedYes


  • Anti-inflammatory
  • Exercise
  • Immune cells
  • Inflammation
  • Metabolic disease
  • Muscle

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