The immunomodulating role of exercise in metabolic disease

Graeme I. Lancaster; Mark A. Febbraio

doi:10.1016/j.it.2014.02.008

The immunomodulating role of exercise in metabolic disease

Graeme I. Lancaster, Mark A. Febbraio

Research output: Contribution to journal › Review Article › Research › peer-review

169 Citations (Scopus)

Abstract

A lack of physical activity is linked to the development of many chronic diseases. It is now well established that the immune system and inflammation play a central role in the development of numerous chronic metabolic diseases including insulin resistance, type 2 diabetes, atherosclerosis, nonalcoholic fatty liver disease, and specific types of cancer. Physical exercise elicits potent anti-inflammatory effects that are likely to account for many of the salutary actions of regular exercise on chronic metabolic diseases. Here we review the anti-inflammatory and immunomodulatory mechanisms by which the beneficial effects of exercise on chronic metabolic diseases may be mediated.

Original language	English
Pages (from-to)	262-269
Number of pages	8
Journal	Trends in Immunology
Volume	35
Issue number	6
DOIs	https://doi.org/10.1016/j.it.2014.02.008
Publication status	Published - Jun 2014
Externally published	Yes

Keywords

Anti-inflammatory
Exercise
Immune cells
Inflammation
Metabolic disease
Muscle

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.it.2014.02.008

Cite this

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AB - A lack of physical activity is linked to the development of many chronic diseases. It is now well established that the immune system and inflammation play a central role in the development of numerous chronic metabolic diseases including insulin resistance, type 2 diabetes, atherosclerosis, nonalcoholic fatty liver disease, and specific types of cancer. Physical exercise elicits potent anti-inflammatory effects that are likely to account for many of the salutary actions of regular exercise on chronic metabolic diseases. Here we review the anti-inflammatory and immunomodulatory mechanisms by which the beneficial effects of exercise on chronic metabolic diseases may be mediated.

KW - Anti-inflammatory

KW - Exercise

KW - Immune cells

KW - Inflammation

KW - Metabolic disease

KW - Muscle

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JO - Trends in Immunology

JF - Trends in Immunology

IS - 6

ER -

The immunomodulating role of exercise in metabolic disease

Abstract

Keywords

UN SDGs

Access to Document

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