The immunogenicity of stem cells and thymus-based strategies to minimise immune rejection

Jessica Morison, Tracy Shu Ping Heng, Ann Patricia Chidgey, Richard Lennox Boyd

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Abstract Stem cell research is advancing at a rapid pace, offering the possibility of personalised, ``made to order?? reparative stem cell treatments. A major challenge, however, is the immunological rejection of the transplanted tissue or `allograft? that is not derived from self. Current clinical practice for overcoming graft rejection is to administer immunosuppressive drugs. Unfortunately these are associated with a number of side effects, including severe and often prolonged immune deficiency, which can lead to complications associated with opportunistic infections. Rather than prolonged global suppression of the immune system, strategies that focus on inducing graft-specific tolerance will provide a more robust and sustained approach to enabling successful translation of stem cell therapies to the clinic.
Original languageEnglish
Title of host publicationThe Immunological Barriers to Regenerative Medicine
EditorsP J Fairchild
Place of PublicationUSA
PublisherHumana Press
Pages201-223
Number of pages23
Edition1st
ISBN (Electronic)9781461454809
ISBN (Print)9781461454793
DOIs
Publication statusPublished - 1 Jan 2013

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