The identification of three novel biomarkers of major adverse kidney events

Michael Haase, Rinaldo Bellomo, Christian Albert, Gregoire Vanpoucke, Griet Thomas, Wouter Laroy, Katleen Verleysen, Siegfried Kropf, Hermann Kuppe, Roland Hetzer, Anja Haase-Fielitz

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17 Citations (Scopus)


Aim: To describe the prognostic value of three novel biomarkers for acute adverse kidney events compared with routine biological markers. Material & methods: We used high-end MS to quantify biomarkers predictive of acute kidney injury (AKI) and major adverse kidney events (MAKE) in 100 adult patients after open heart surgery (n = 100). Results: Early postoperatively measured LG3 (a C-terminal fragment of perlecan), LTBP2 (latent transforming growth factor binding protein-2), Cathepsin L as well as two other renal biomarkers (NGAL, Cystatin C) had greater predictive value for AKI (n = 23) and MAKE (n = 24) compared with creatinine, urea and urine output. Conclusions: LG3, LTBP2 and Cathepsin L deserve further exploration as biomarkers for the early identification of patients at risk of MAKE.

Original languageEnglish
Pages (from-to)1207-1217
Number of pages11
JournalBiomarkers in Medicine
Issue number10
Publication statusPublished - Dec 2014
Externally publishedYes


  • C-terminal fragment of perlecan
  • cathepsin L
  • creatinine
  • cystatin C
  • latent transforming growth factor binding protein-2
  • LG3
  • LTBP2
  • major adverse kidney event
  • MAKE
  • neutrophil gelatinase-associated lipocalin
  • NGAL
  • urea
  • urine output

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