The ICM research agenda on extracorporeal life support

Alain Combes, Dan Brodie, Yih Sharng Chen, Eddy Fan, José P.S. Henriques, Carol Hodgson, Philipp M. Lepper, Pascal Leprince, Kunihiko Maekawa, Thomas Muller, Sebastian Nuding, Dagmar M. Ouweneel, Antoine Roch, Matthieu Schmidt, Hiroo Takayama, Alain Vuylsteke, Karl Werdan, Laurent Papazian

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Abstract

Purpose: This study aimed to concisely describe the current standards of care, major recent advances, common beliefs that have been contradicted by recent trials, areas of uncertainty, and clinical studies that need to be performed over the next decade and their expected outcomes with regard to extracorporeal membrane oxygenation (ECMO). Methods: Narrative review based on a systematic analysis of the medical literature, national and international guidelines, and expert opinion. Results: The use of venovenous ECMO (VV-ECMO) is increasing in the most severe forms of acute lung injury. In patients with cardiogenic shock, short-term veno-arterial ECMO (VA-ECMO) provides both pulmonary and circulatory support. Technological improvements and recently published studies suggest that ECMO is able to improve patients’ outcomes. There are, however, many uncertainties regarding the real benefits of this technique both in hemodynamic and respiratory failure, the territorial organization to deliver ECMO, the indications and the use of concomitant treatments. Conclusions: Although there have been considerable advances regarding the use of ECMO in critically ill patients, the risk/benefit ratio remains underinvestigated. ECMO indications, organization of ECMO delivery, and use of adjuvant therapeutics need also to be explored. Ongoing and future studies may be able to resolve these issues.

Original languageEnglish
Pages (from-to)1306-1318
Number of pages13
JournalIntensive Care Medicine
Volume43
Issue number9
DOIs
Publication statusPublished - Sep 2017

Keywords

  • Acute respiratory distress syndrome
  • Cardiogenic shock
  • Extracorporeal membrane oxygenation
  • Position article
  • Research agenda

Cite this

Combes, A., Brodie, D., Chen, Y. S., Fan, E., Henriques, J. P. S., Hodgson, C., ... Papazian, L. (2017). The ICM research agenda on extracorporeal life support. Intensive Care Medicine, 43(9), 1306-1318. https://doi.org/10.1007/s00134-017-4803-3
Combes, Alain ; Brodie, Dan ; Chen, Yih Sharng ; Fan, Eddy ; Henriques, José P.S. ; Hodgson, Carol ; Lepper, Philipp M. ; Leprince, Pascal ; Maekawa, Kunihiko ; Muller, Thomas ; Nuding, Sebastian ; Ouweneel, Dagmar M. ; Roch, Antoine ; Schmidt, Matthieu ; Takayama, Hiroo ; Vuylsteke, Alain ; Werdan, Karl ; Papazian, Laurent. / The ICM research agenda on extracorporeal life support. In: Intensive Care Medicine. 2017 ; Vol. 43, No. 9. pp. 1306-1318.
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Combes, A, Brodie, D, Chen, YS, Fan, E, Henriques, JPS, Hodgson, C, Lepper, PM, Leprince, P, Maekawa, K, Muller, T, Nuding, S, Ouweneel, DM, Roch, A, Schmidt, M, Takayama, H, Vuylsteke, A, Werdan, K & Papazian, L 2017, 'The ICM research agenda on extracorporeal life support', Intensive Care Medicine, vol. 43, no. 9, pp. 1306-1318. https://doi.org/10.1007/s00134-017-4803-3

The ICM research agenda on extracorporeal life support. / Combes, Alain; Brodie, Dan; Chen, Yih Sharng; Fan, Eddy; Henriques, José P.S.; Hodgson, Carol; Lepper, Philipp M.; Leprince, Pascal; Maekawa, Kunihiko; Muller, Thomas; Nuding, Sebastian; Ouweneel, Dagmar M.; Roch, Antoine; Schmidt, Matthieu; Takayama, Hiroo; Vuylsteke, Alain; Werdan, Karl; Papazian, Laurent.

In: Intensive Care Medicine, Vol. 43, No. 9, 09.2017, p. 1306-1318.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Combes, Alain

AU - Brodie, Dan

AU - Chen, Yih Sharng

AU - Fan, Eddy

AU - Henriques, José P.S.

AU - Hodgson, Carol

AU - Lepper, Philipp M.

AU - Leprince, Pascal

AU - Maekawa, Kunihiko

AU - Muller, Thomas

AU - Nuding, Sebastian

AU - Ouweneel, Dagmar M.

AU - Roch, Antoine

AU - Schmidt, Matthieu

AU - Takayama, Hiroo

AU - Vuylsteke, Alain

AU - Werdan, Karl

AU - Papazian, Laurent

PY - 2017/9

Y1 - 2017/9

N2 - Purpose: This study aimed to concisely describe the current standards of care, major recent advances, common beliefs that have been contradicted by recent trials, areas of uncertainty, and clinical studies that need to be performed over the next decade and their expected outcomes with regard to extracorporeal membrane oxygenation (ECMO). Methods: Narrative review based on a systematic analysis of the medical literature, national and international guidelines, and expert opinion. Results: The use of venovenous ECMO (VV-ECMO) is increasing in the most severe forms of acute lung injury. In patients with cardiogenic shock, short-term veno-arterial ECMO (VA-ECMO) provides both pulmonary and circulatory support. Technological improvements and recently published studies suggest that ECMO is able to improve patients’ outcomes. There are, however, many uncertainties regarding the real benefits of this technique both in hemodynamic and respiratory failure, the territorial organization to deliver ECMO, the indications and the use of concomitant treatments. Conclusions: Although there have been considerable advances regarding the use of ECMO in critically ill patients, the risk/benefit ratio remains underinvestigated. ECMO indications, organization of ECMO delivery, and use of adjuvant therapeutics need also to be explored. Ongoing and future studies may be able to resolve these issues.

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KW - Cardiogenic shock

KW - Extracorporeal membrane oxygenation

KW - Position article

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Combes A, Brodie D, Chen YS, Fan E, Henriques JPS, Hodgson C et al. The ICM research agenda on extracorporeal life support. Intensive Care Medicine. 2017 Sep;43(9):1306-1318. https://doi.org/10.1007/s00134-017-4803-3