The human placenta: A novel source of inhibin

R. I. McLachlan; D. L. Healy; D. M. Robertson; H. G. Burger; D. M. de Kretser

doi:10.1016/0006-291X(86)90758-8

The human placenta: A novel source of inhibin

R. I. McLachlan, D. L. Healy, D. M. Robertson, H. G. Burger, D. M. de Kretser

Hudson Institute - Department of Molecular and Translational Science

Research output: Contribution to journal › Article › Research › peer-review

102 Citations (Scopus)

Abstract

Human placental extracts contain inhibin bioactivity and immunoactivity giving dose response curves parallel to a human follicular fluid inhibin standard. Inhibin bioactivity in vitro was neutralised by preincubation of extracts with antisera raised to pure bovine inhibin. Umbilical cord blood from term infants contained immunoactivity. Human placental inhibin differs from human ovarian inhibin in terms of its biological:immunological ratio.

Original language	English
Pages (from-to)	485-490
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	140
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(86)90758-8
Publication status	Published - 30 Oct 1986

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AU - de Kretser, D. M.

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AB - Human placental extracts contain inhibin bioactivity and immunoactivity giving dose response curves parallel to a human follicular fluid inhibin standard. Inhibin bioactivity in vitro was neutralised by preincubation of extracts with antisera raised to pure bovine inhibin. Umbilical cord blood from term infants contained immunoactivity. Human placental inhibin differs from human ovarian inhibin in terms of its biological:immunological ratio.

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The human placenta: A novel source of inhibin

Abstract

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