The Human Kidney: Parallels in Structure, Spatial Development, and Timing of Nephrogenesis

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Abstract

Over the recent decades there has been extensive investigation into the genetic/molecular regulation and cellular/molecular mechanisms of nephrogenesis and ultimate kidney development in animal models, but to date these have not been examined in the human kidney. This chapter highlights the differences in the anatomic structure and spatial and temporal ontogeny of the kidney in animal models compared to humans. In doing so, it emphasizes that caution needs to be taken when extrapolating findings from animal models to humans.

Original languageEnglish
Title of host publicationKidney Development, Disease, Repair and Regeneration
EditorsM Little
Place of PublicationUK
PublisherAcademic Press
Pages27-40
Number of pages14
Edition1st
ISBN (Electronic)9780128004388
ISBN (Print)9780128001028
DOIs
Publication statusPublished - 2016

Keywords

  • Arcades
  • Branching morphogenesis
  • Nephrogenesis
  • Nephron endowment
  • Papillae

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