The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13

Janine H. Van Ree; Marie A. Roskrow; Anna M. Becher; Renée McNall; Virginia A. Valentine; Stephen M. Jane; John M. Cunningham

doi:10.1006/geno.1996.4472

The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13

Janine H. Van Ree, Marie A. Roskrow, Anna M. Becher, Renée McNall, Virginia A. Valentine, Stephen M. Jane, John M. Cunningham

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

Erythroid Kruppel-like factor (EKLF) is a trans-acting factor that binds specifically to the β-globin promoter CACCC box. EKLF is essential for adult erythroid development in mice. We have cloned and sequenced a cDNA encoding the human homologue of this gene, which shares 69% identity with the mEKLF protein. The expression of hEKLF is restricted to fetal liver and adult bone marrow. The genomic locus of hEKLF was mapped to chromosomal band 19p13.12- p13.13, using fluorescence in situ hybridization.

Original language	English
Pages (from-to)	393-395
Number of pages	3
Journal	Genomics
Volume	39
Issue number	3
DOIs	https://doi.org/10.1006/geno.1996.4472
Publication status	Published - 1 Feb 1997
Externally published	Yes

Access to Document

10.1006/geno.1996.4472

Cite this

@article{84a6355e4a1b4038b7bd015c4c60fca1,

title = "The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13",

abstract = "Erythroid Kruppel-like factor (EKLF) is a trans-acting factor that binds specifically to the β-globin promoter CACCC box. EKLF is essential for adult erythroid development in mice. We have cloned and sequenced a cDNA encoding the human homologue of this gene, which shares 69% identity with the mEKLF protein. The expression of hEKLF is restricted to fetal liver and adult bone marrow. The genomic locus of hEKLF was mapped to chromosomal band 19p13.12- p13.13, using fluorescence in situ hybridization.",

author = "{Van Ree}, {Janine H.} and Roskrow, {Marie A.} and Becher, {Anna M.} and Ren{\'e}e McNall and Valentine, {Virginia A.} and Jane, {Stephen M.} and Cunningham, {John M.}",

year = "1997",

month = feb,

day = "1",

doi = "10.1006/geno.1996.4472",

language = "English",

volume = "39",

pages = "393--395",

journal = "Genomics",

issn = "0888-7543",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13

AU - Van Ree, Janine H.

AU - Roskrow, Marie A.

AU - Becher, Anna M.

AU - McNall, Renée

AU - Valentine, Virginia A.

AU - Jane, Stephen M.

AU - Cunningham, John M.

PY - 1997/2/1

Y1 - 1997/2/1

N2 - Erythroid Kruppel-like factor (EKLF) is a trans-acting factor that binds specifically to the β-globin promoter CACCC box. EKLF is essential for adult erythroid development in mice. We have cloned and sequenced a cDNA encoding the human homologue of this gene, which shares 69% identity with the mEKLF protein. The expression of hEKLF is restricted to fetal liver and adult bone marrow. The genomic locus of hEKLF was mapped to chromosomal band 19p13.12- p13.13, using fluorescence in situ hybridization.

AB - Erythroid Kruppel-like factor (EKLF) is a trans-acting factor that binds specifically to the β-globin promoter CACCC box. EKLF is essential for adult erythroid development in mice. We have cloned and sequenced a cDNA encoding the human homologue of this gene, which shares 69% identity with the mEKLF protein. The expression of hEKLF is restricted to fetal liver and adult bone marrow. The genomic locus of hEKLF was mapped to chromosomal band 19p13.12- p13.13, using fluorescence in situ hybridization.

UR - http://www.scopus.com/inward/record.url?scp=0031081372&partnerID=8YFLogxK

U2 - 10.1006/geno.1996.4472

DO - 10.1006/geno.1996.4472

M3 - Article

C2 - 9119377

AN - SCOPUS:0031081372

SN - 0888-7543

VL - 39

SP - 393

EP - 395

JO - Genomics

JF - Genomics

IS - 3

ER -

The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13

Abstract

Access to Document

Other files and links

Cite this