The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13

Janine H. Van Ree, Marie A. Roskrow, Anna M. Becher, Renée McNall, Virginia A. Valentine, Stephen M. Jane, John M. Cunningham

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Abstract

Erythroid Kruppel-like factor (EKLF) is a trans-acting factor that binds specifically to the β-globin promoter CACCC box. EKLF is essential for adult erythroid development in mice. We have cloned and sequenced a cDNA encoding the human homologue of this gene, which shares 69% identity with the mEKLF protein. The expression of hEKLF is restricted to fetal liver and adult bone marrow. The genomic locus of hEKLF was mapped to chromosomal band 19p13.12- p13.13, using fluorescence in situ hybridization.

Original languageEnglish
Pages (from-to)393-395
Number of pages3
JournalGenomics
Volume39
Issue number3
DOIs
Publication statusPublished - 1 Feb 1997
Externally publishedYes

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