The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses

Liam Kealy, Andrea Di Pietro, Lauren Hailes, Sebastian Scheer, Lennard Dalit, Joanna R. Groom, Colby Zaph, Kim L. Good-Jacobson

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

B cell differentiation is critical for antibody-mediated clearance of pathogens. Kealy et al. show a key role for the histone modifier DOT1L in B cell responses. DOT1L is essential for appropriate localization of B cells to form germinal centers, the critical sites for producing high-affinity antibody and B cell memory.

Original languageEnglish
Article number108504
Number of pages16
JournalCell Reports
Volume33
Issue number11
DOIs
Publication statusPublished - 15 Dec 2020

Keywords

  • antibody
  • B cells
  • DOT1L
  • epigenetics
  • H3K79
  • humoral responses

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