TY - JOUR
T1 - The "his and hers" of the renin-angiotensin system
AU - Hilliard, Lucinda M
AU - Sampson, Amanda K
AU - Brown, Russell D
AU - Denton, Katherine M
PY - 2013
Y1 - 2013
N2 - Sex differences exist in the regulation of arterial pressure and renal function by the renin-angiotensin system (RAS). This may in part stem from a differential balance in the pressor and depressor arms of the RAS. In males, the ACE/AngII/AT(1)R pathways are enhanced, whereas, in females, the balance is shifted towards the ACE2/Ang(1-7)/MasR and AT(2)R pathways. Evidence clearly demonstrates that premenopausal women, as compared to aged-matched men, are protected from renal and cardiovascular disease, and this differential balance of the RAS between the sexes likely contributes. With aging, this cardiovascular protection in women is lost and this may be related to loss of estrogen postmenopause but the possible contribution of other sex hormones needs to be further examined. Restoration of these RAS depressor pathways in older women, or up-regulation of these in males, represents a therapeutic target that is worth pursuing.
AB - Sex differences exist in the regulation of arterial pressure and renal function by the renin-angiotensin system (RAS). This may in part stem from a differential balance in the pressor and depressor arms of the RAS. In males, the ACE/AngII/AT(1)R pathways are enhanced, whereas, in females, the balance is shifted towards the ACE2/Ang(1-7)/MasR and AT(2)R pathways. Evidence clearly demonstrates that premenopausal women, as compared to aged-matched men, are protected from renal and cardiovascular disease, and this differential balance of the RAS between the sexes likely contributes. With aging, this cardiovascular protection in women is lost and this may be related to loss of estrogen postmenopause but the possible contribution of other sex hormones needs to be further examined. Restoration of these RAS depressor pathways in older women, or up-regulation of these in males, represents a therapeutic target that is worth pursuing.
UR - http://download.springer.com/static/pdf/749/art%253A10.1007%252Fs11906-012-0319-y.pdf?auth66=1385609872_a2d66d2a9c0e21125a025aa601214f41&ext=.pdf
U2 - 10.1007/s11906-012-0319-y
DO - 10.1007/s11906-012-0319-y
M3 - Article
SN - 1522-6417
VL - 15
SP - 71
EP - 79
JO - Current Hypertension Reports
JF - Current Hypertension Reports
IS - 1
ER -
