TY - JOUR
T1 - The high-affinity receptor for IgG, FcgammaRI, of humans and non-human primates
AU - Chenoweth, Alicia M
AU - Trist, Halina
AU - Tan, Peck Szee
AU - Wines, Bruce D
AU - Hogarth, Phillip Mark
PY - 2015
Y1 - 2015
N2 - Non-human primate (NHP) models, especially involving macaques, are considered important models of human immunity and have been essential in preclinical testing for vaccines and therapeutics. Despite this, much less characterization of macaque Fc receptors has occurred compared to humans or mice. Much of the characterization of macaque Fc receptors so far has focused on the low-affinity Fc receptors, particularly Fc?RIIIa. From these studies, it is clear that there are distinct differences between the human and macaque low-affinity receptors and their interaction with human IgG. Relatively little work has been performed on the high-affinity IgG receptor, Fc?RI, especially in NHPs. This review will focus on what is currently known of how Fc?RI interacts with IgG, from mutation studies and recent crystallographic studies of human Fc?RI, and how amino acid sequence differences in the macaque Fc?RI may affect this interaction. Additionally, this review will look at the functional consequences of differences in the amino acid sequences between humans and macaques. ? 2015 John Wiley Sons A/S.
AB - Non-human primate (NHP) models, especially involving macaques, are considered important models of human immunity and have been essential in preclinical testing for vaccines and therapeutics. Despite this, much less characterization of macaque Fc receptors has occurred compared to humans or mice. Much of the characterization of macaque Fc receptors so far has focused on the low-affinity Fc receptors, particularly Fc?RIIIa. From these studies, it is clear that there are distinct differences between the human and macaque low-affinity receptors and their interaction with human IgG. Relatively little work has been performed on the high-affinity IgG receptor, Fc?RI, especially in NHPs. This review will focus on what is currently known of how Fc?RI interacts with IgG, from mutation studies and recent crystallographic studies of human Fc?RI, and how amino acid sequence differences in the macaque Fc?RI may affect this interaction. Additionally, this review will look at the functional consequences of differences in the amino acid sequences between humans and macaques. ? 2015 John Wiley Sons A/S.
UR - http://onlinelibrary.wiley.com/doi/10.1111/imr.12366/epdf
U2 - 10.1111/imr.12366
DO - 10.1111/imr.12366
M3 - Article
SN - 0105-2896
VL - 268
SP - 175
EP - 191
JO - Immunological Reviews
JF - Immunological Reviews
IS - 1
ER -