The heterosexual HIV type 1 epidemic in Papua New Guinea is dominated by subtype C

Claire E Ryan, Janet Gare, Suzanne Mary Crowe, Kim Wilson, John C Reeder, Robert B Oelrichs

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Abstract

Papua New Guinea is in the midst of a generalized HIV epidemic. As part of a larger behavioral survey aiming to further characterize the HIV epidemic occurring in PNG, samples were collected from 1175 participants from seven different provinces. Seventy-one (6 ) of these samples were HIV-1 positive, and 35 (49 ) successfully underwent a double nested RT-PCR that was designed to amplify the C2-V4 region of the HIV-1 envelope. Sequence analysis showed that 33 (94 ) samples were subtype C and the remaining 2 (6 ) were subtype B. Further phylogenetic analysis demonstrated that there was no province-specific clustering among the samples and that within the global pandemic, PNG subtype C isolates most closely resembled those from East Africa.
Original languageEnglish
Pages (from-to)941 - 944
Number of pages4
JournalAIDS Research and Human Retroviruses
Volume23
Issue number7
DOIs
Publication statusPublished - 2007

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