The haemodynamic effects of bolus versus slower infusion of intravenous crystalloid in healthy volunteers

Ida F. Ukor, Andrew K. Hilton, Michael J. Bailey, Rinaldo Bellomo

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13 Citations (Scopus)


Purpose This pilot study aimed to characterise the haemodynamic effect of 1L of IV normal saline (NS) administered as a rapid versus slow infusion on cardiac output (CO), heart rate (HR), systemic blood pressures, and carotid blood flow in six healthy volunteers. Materials and methods Six healthy male volunteers aged 18–65 years were randomized to receive 1L NS given over 30 min or 120 min. On a subsequent study session the alternate fluid regimen was administered. Haemodynamic data was gathered using a non-invasive finger arterial pressure monitor (Nexfin®), echocardiography and carotid duplex sonography. Time to micturition and urine volume was also assessed. Results Compared to baseline, rapid infusion of 1 L of saline over 30 min produced a fall in Nexfin®-measured CO by 0.62 L/min (p < 0.001), whereas there was a marginal but significant increase during infusion of 1L NS over 120 min of 0.02 L/min (p < 0.001). This effect was mirrored by changes in HR and blood pressure (BP) (p < 0.001). There were no significant changes in carotid blood flow, time to micturition, or urine volume produced. Conclusions Slower infusion of 1L NS in healthy male volunteers produced a greater increase in CO, HR and BP than rapid infusion.

Original languageEnglish
Pages (from-to)254-259
Number of pages6
JournalJournal of Critical Care
Publication statusPublished - 1 Oct 2017


  • Cardiac output
  • Fluid therapy
  • Haemodynamics
  • Healthy volunteers
  • Noninvasive monitoring
  • Resuscitation
  • Saline

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