The Grb7 family of signalling proteins

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Abstract

The Grb7 family is a rapidly emerging group of Src homology (SH)2 domain-containing signalling proteins that currently contains three members, Grb7, 10 and 14. These proteins possess a conserved multidomain structure, including a central region exhibiting significant homology to the Caenorhabditis elegans protein Mig10. Differences in tissue expression and SH2 binding selectivity suggest that these adaptor proteins function in a tissue specific manner to link specific receptor tyrosine kinases (RTKs) and other tyrosine phosphorylated proteins to as yet uncharacterised downstream effecters. Interestingly, Grb7 proteins exhibit differential expression amongst a variety of human cancers and cancer cell lines. Consequently, these proteins not only are likely to perform a fundamental signalling role, but may also modulate RTK signalling in cancer cells.

Original languageEnglish
Pages (from-to)613-618
Number of pages6
JournalCellular Signalling
Volume10
Issue number9
DOIs
Publication statusPublished - 1 Oct 1998
Externally publishedYes

Keywords

  • Grb7
  • Mig 10
  • SH2 domain
  • Tyrosine kinase

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