Abstract
The Grb7 family is a rapidly emerging group of Src homology (SH)2 domain-containing signalling proteins that currently contains three members, Grb7, 10 and 14. These proteins possess a conserved multidomain structure, including a central region exhibiting significant homology to the Caenorhabditis elegans protein Mig10. Differences in tissue expression and SH2 binding selectivity suggest that these adaptor proteins function in a tissue specific manner to link specific receptor tyrosine kinases (RTKs) and other tyrosine phosphorylated proteins to as yet uncharacterised downstream effecters. Interestingly, Grb7 proteins exhibit differential expression amongst a variety of human cancers and cancer cell lines. Consequently, these proteins not only are likely to perform a fundamental signalling role, but may also modulate RTK signalling in cancer cells.
Original language | English |
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Pages (from-to) | 613-618 |
Number of pages | 6 |
Journal | Cellular Signalling |
Volume | 10 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1 Oct 1998 |
Externally published | Yes |
Keywords
- Grb7
- Mig 10
- SH2 domain
- Tyrosine kinase