The glucocorticoid receptor is required for experimental adrenocorticotrophic hormone-induced hypertension in mice

Yi Zhang, Chris G Schyvens, Timothy J Cole, Katja US McKenzie, Janine J Vickers, Judith Ann Whitworth

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Summary 1. In the present study, we have 1) measured basal blood pressure by telemetry in wild type (WT) and glucocorticoid receptor knockout (GRKO); 2) investigated whether ACTH can induce hypertension in GRKO mice, and 3) investigated the effect of mineralocortocoid receptor blockade on the cardiovascular physiology of GRKO mice. 2. Male WT and GRKO mice were treated with ACTH (2 mg/kg/day s.c.) or spironolactone (100 mg/kg/day, s.c.) for 1-2 weeks. Blood pressure (BP) was measured using a radio-telemetry system. Urinary Na:K, blood glucose concentrations and haematocrit were also measured during the treatment period. 3. Baseline systolic blood pressure (SBP) was higher in GRKO mice (126+/-4 mmHg, mean+/-SEM, n=11) than WT mice (114+/-2 mmHg, n=10; P
Original languageEnglish
Pages (from-to)1044 - 1048
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume37
Issue number11
DOIs
Publication statusPublished - 2010

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