The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism

Norbert Stefan, Barbora de Courten, Angelo Del Parigi, V Ossowski, Darren Bruce Thompson, Eric Ravussin, P Antonio Tataranni, Robert Hanson

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Abstract

Leptin regulates body weight by its receptor-mediated anorectic, thermogenic and antisteatotic effects. Recently, lower leptin binding to the soluble form of the leptin receptor (LEPR) was shown in carriers of the Arg223-encoding allele of the Gln223Arg polymorphism of the LEPR. To investigate whether this variant influences energy metabolism and adiposity in Pima Indians, we genotyped non-diabetic Pima Indians in whom we had measured body composition and 24 h energy expenditure (24 h EE), physical activity level (PAL) and 24 h respiratory quotient (24 h RQ) in a respiratory chamber (n=268) and who had undergone percutaneous fat biopsies from the periumbilical region (n=184). Genotype was not associated with percent body fat (P>0.39), but was associated with 24 h EE, PAL and mean subcutaneous abdominal adipocyte size (SAAS all P
Original languageEnglish
Pages (from-to)1629 - 1632
Number of pages4
JournalInternational Journal of Obesity
Volume26
Issue number12
Publication statusPublished - 2002

Cite this

Stefan, N., de Courten, B., Parigi, A. D., Ossowski, V., Thompson, D. B., Ravussin, E., Tataranni, P. A., & Hanson, R. (2002). The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. International Journal of Obesity, 26(12), 1629 - 1632.