Abstract
The generation of complete genome sequences provides a blueprint that facilitates the genetic characterization of pathogens and their hosts. The genome of Salmonella enterica serovar Typhi (S. Typhi) harbors ∼5 million base pairs encoding some 4000 genes, of which >200 are functionally inactive. Comparison of S. Typhi isolates from around the world indicates that they are highly related (clonal) and that they emerged from a single point of origin ∼30,000-50,000 years ago. Evidence suggests that, as well as undergoing gene degradation, S. Typhi has also recently acquired genes, such as those encoding the Vi antigen, by horizontal transfer events.
| Original language | English |
|---|---|
| Journal | Clinical Infectious Diseases |
| Volume | 45 |
| DOIs | |
| Publication status | Published - 15 Jul 2007 |
| Externally published | Yes |
Cite this
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The genome of Salmonella enterica serovar typhi. / Baker, Stephen; Dougan, Gordon.
In: Clinical Infectious Diseases, Vol. 45, 15.07.2007.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - The genome of Salmonella enterica serovar typhi
AU - Baker, Stephen
AU - Dougan, Gordon
PY - 2007/7/15
Y1 - 2007/7/15
N2 - The generation of complete genome sequences provides a blueprint that facilitates the genetic characterization of pathogens and their hosts. The genome of Salmonella enterica serovar Typhi (S. Typhi) harbors ∼5 million base pairs encoding some 4000 genes, of which >200 are functionally inactive. Comparison of S. Typhi isolates from around the world indicates that they are highly related (clonal) and that they emerged from a single point of origin ∼30,000-50,000 years ago. Evidence suggests that, as well as undergoing gene degradation, S. Typhi has also recently acquired genes, such as those encoding the Vi antigen, by horizontal transfer events.
AB - The generation of complete genome sequences provides a blueprint that facilitates the genetic characterization of pathogens and their hosts. The genome of Salmonella enterica serovar Typhi (S. Typhi) harbors ∼5 million base pairs encoding some 4000 genes, of which >200 are functionally inactive. Comparison of S. Typhi isolates from around the world indicates that they are highly related (clonal) and that they emerged from a single point of origin ∼30,000-50,000 years ago. Evidence suggests that, as well as undergoing gene degradation, S. Typhi has also recently acquired genes, such as those encoding the Vi antigen, by horizontal transfer events.
UR - http://www.scopus.com/inward/record.url?scp=34447126310&partnerID=8YFLogxK
U2 - 10.1086/518143
DO - 10.1086/518143
M3 - Review Article
VL - 45
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
ER -