The generation of antibody-secreting plasma cells

Stewart L Nutt, Philip D. Hodgkin, David M. Tarlinton, Lynn M. Corcoran

Research output: Contribution to journalArticleOtherpeer-review

453 Citations (Scopus)

Abstract

The regulation of antibody production is linked to the generation and maintenance of plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly produced and short-lived effector cells of the early antibody response, whereas plasma cells are the long-lived mediators of lasting humoral immunity. An extraordinary number of control mechanisms, at both the cellular and molecular levels, underlie the regulation of this essential arm of the immune response. Despite this complexity, the terminal differentiation of B cells can be described as a simple probabilistic process that is governed by a central gene-regulatory network and modified by environmental stimuli.
Original languageEnglish
Pages (from-to)160 - 171
Number of pages12
JournalNature Reviews Immunology
Volume15
Issue number3
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Antibodies
  • B cells
  • Plasma cells
  • Transcription factors

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