TY - JOUR
T1 - The gastro-protective effect of ginger (Zingiber officinale roscoe) in Helicobacter pylori positive functional dyspepsia
AU - Attari, Vahideh Ebrahimzadeh
AU - Somi, Mohammad Hosein
AU - Jafarabadi, Mohammad Asghari
AU - Ostadrahimi, Alireza
AU - Moaddab, Seyed Yaghob
AU - Lotfi, Neda
N1 - Funding Information:
This study was supported by a grant from Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Publisher Copyright:
© 2019 The Author (s).
PY - 2019
Y1 - 2019
N2 - Purpose: The present study aimed to assess the effect of ginger (Zingiber officinale) powder supplementation on Helicobacter pylori eradication and improvement of dyspeptic symptoms in patients with H. pylori positive functional dyspepsia (FD). Methods: During this pilot study 15 patients with H. pylori positive FD received 3 g/d ginger powder as three 1-g tablets for 4-weeks. Dyspepsia symptoms were asked before and after the intervention using a questionnaire based on the Rome III criteria. H. pylori eradication was also assessed by a non-invasive stool antigen (HpSAg) test. Results: Ginger consumption accompanied by significant H. pylori eradication rate of 53.3% (P = 0.019) and the odds ratio (95% CI) was 8 (1.07 to 357.14). Moreover, our results showed significant changes in most of the dyspepsia symptoms after ginger supplementation. Conclusion: According to our findings, Z. officinale can be considered as a useful complementary therapy for FD. However, due to the small number of clinical trials in this area, further well-designed clinical trials are needed to explicitly talk about its effectiveness especially about the eradication of H. pylori.
AB - Purpose: The present study aimed to assess the effect of ginger (Zingiber officinale) powder supplementation on Helicobacter pylori eradication and improvement of dyspeptic symptoms in patients with H. pylori positive functional dyspepsia (FD). Methods: During this pilot study 15 patients with H. pylori positive FD received 3 g/d ginger powder as three 1-g tablets for 4-weeks. Dyspepsia symptoms were asked before and after the intervention using a questionnaire based on the Rome III criteria. H. pylori eradication was also assessed by a non-invasive stool antigen (HpSAg) test. Results: Ginger consumption accompanied by significant H. pylori eradication rate of 53.3% (P = 0.019) and the odds ratio (95% CI) was 8 (1.07 to 357.14). Moreover, our results showed significant changes in most of the dyspepsia symptoms after ginger supplementation. Conclusion: According to our findings, Z. officinale can be considered as a useful complementary therapy for FD. However, due to the small number of clinical trials in this area, further well-designed clinical trials are needed to explicitly talk about its effectiveness especially about the eradication of H. pylori.
KW - Dyspepsia
KW - Gastric motility
KW - Ginger
KW - Helicobacter pylori
KW - Zingiber officinale
UR - https://www.scopus.com/pages/publications/85068540820
U2 - 10.15171/apb.2019.038
DO - 10.15171/apb.2019.038
M3 - Article
C2 - 31380260
AN - SCOPUS:85068540820
SN - 2228-5881
VL - 9
SP - 321
EP - 324
JO - Advanced Pharmaceutical Bulletin
JF - Advanced Pharmaceutical Bulletin
IS - 2
ER -