The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: The action in diabetes and vascular disease: Pre

Andre-Pascal Kengne; Anushka Patel; Stephen Colagiuri; S Heller; Pavel Hamet; Michel Marre; C Pan; Sophia Zoungas; Diederick Grobbee; Bruce Neal; John Chalmers; Mark Woodward

doi:10.1007/s00125-010-1681-4

The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: The action in diabetes and vascular disease: Pre

Andre-Pascal Kengne, Anushka Patel, Stephen Colagiuri, S Heller, Pavel Hamet, Michel Marre, C Pan, Sophia Zoungas, Diederick Grobbee, Bruce Neal, John Chalmers, Mark Woodward

School of Public Health and Preventive Medicine

Research output: Contribution to journal › Article › Research › peer-review

107 Citations (Scopus)

Abstract

Aims/hypothesis Available multivariable equations for cardiovascular risk assessment in people with diabetes have been derived either from the general population or from populations with diabetes. Their utility and comparative performance in a contemporary group of patients with type 2 diabetes are not well established. The aim of this study was to evaluate the performance of the Framingham and UK Prospective Diabetes Study (UKPDS) risk equations in participants who took part in the Action in Diabetes and Vascular disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) trial. Methods The 4-year risks of cardiovascular disease (CVD) and its constituents were estimated using two published Framingham and the UKPDS risk equations in 7,502 individuals with type 2 diabetes without prior known CVD at their enrolment in the trial. Conclusions/interpretation Application of the Framingham and UKPDS risk equations to a contemporary treated group of patients with established type 2 diabetes is likely to substantially overestimate cardiovascular risk.

Original language	English
Pages (from-to)	821 - 831
Number of pages	11
Journal	Diabetologia
Volume	53
Issue number	5
DOIs	https://doi.org/10.1007/s00125-010-1681-4
Publication status	Published - 2010

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Kengne, A.-P., Patel, A., Colagiuri, S., Heller, S., Hamet, P., Marre, M., Pan, C., Zoungas, S., Grobbee, D., Neal, B., Chalmers, J., & Woodward, M. (2010). The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: The action in diabetes and vascular disease: Pre. Diabetologia, 53(5), 821 - 831. https://doi.org/10.1007/s00125-010-1681-4

Kengne, Andre-Pascal ; Patel, Anushka ; Colagiuri, Stephen et al. / The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: The action in diabetes and vascular disease: Pre. In: Diabetologia. 2010 ; Vol. 53, No. 5. pp. 821 - 831.

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title = "The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: The action in diabetes and vascular disease: Pre",

abstract = "Aims/hypothesis Available multivariable equations for cardiovascular risk assessment in people with diabetes have been derived either from the general population or from populations with diabetes. Their utility and comparative performance in a contemporary group of patients with type 2 diabetes are not well established. The aim of this study was to evaluate the performance of the Framingham and UK Prospective Diabetes Study (UKPDS) risk equations in participants who took part in the Action in Diabetes and Vascular disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) trial. Methods The 4-year risks of cardiovascular disease (CVD) and its constituents were estimated using two published Framingham and the UKPDS risk equations in 7,502 individuals with type 2 diabetes without prior known CVD at their enrolment in the trial. Conclusions/interpretation Application of the Framingham and UKPDS risk equations to a contemporary treated group of patients with established type 2 diabetes is likely to substantially overestimate cardiovascular risk.",

author = "Andre-Pascal Kengne and Anushka Patel and Stephen Colagiuri and S Heller and Pavel Hamet and Michel Marre and C Pan and Sophia Zoungas and Diederick Grobbee and Bruce Neal and John Chalmers and Mark Woodward",

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language = "English",

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Kengne, A-P, Patel, A, Colagiuri, S, Heller, S, Hamet, P, Marre, M, Pan, C, Zoungas, S, Grobbee, D, Neal, B, Chalmers, J & Woodward, M 2010, 'The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: The action in diabetes and vascular disease: Pre', Diabetologia, vol. 53, no. 5, pp. 821 - 831. https://doi.org/10.1007/s00125-010-1681-4

The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: The action in diabetes and vascular disease: Pre. / Kengne, Andre-Pascal; Patel, Anushka; Colagiuri, Stephen et al.
In: Diabetologia, Vol. 53, No. 5, 2010, p. 821 - 831.

Research output: Contribution to journal › Article › Research › peer-review

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T1 - The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: The action in diabetes and vascular disease: Pre

AU - Kengne, Andre-Pascal

AU - Patel, Anushka

AU - Colagiuri, Stephen

AU - Heller, S

AU - Hamet, Pavel

AU - Marre, Michel

AU - Pan, C

AU - Zoungas, Sophia

AU - Grobbee, Diederick

AU - Neal, Bruce

AU - Chalmers, John

AU - Woodward, Mark

PY - 2010

Y1 - 2010

N2 - Aims/hypothesis Available multivariable equations for cardiovascular risk assessment in people with diabetes have been derived either from the general population or from populations with diabetes. Their utility and comparative performance in a contemporary group of patients with type 2 diabetes are not well established. The aim of this study was to evaluate the performance of the Framingham and UK Prospective Diabetes Study (UKPDS) risk equations in participants who took part in the Action in Diabetes and Vascular disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) trial. Methods The 4-year risks of cardiovascular disease (CVD) and its constituents were estimated using two published Framingham and the UKPDS risk equations in 7,502 individuals with type 2 diabetes without prior known CVD at their enrolment in the trial. Conclusions/interpretation Application of the Framingham and UKPDS risk equations to a contemporary treated group of patients with established type 2 diabetes is likely to substantially overestimate cardiovascular risk.

AB - Aims/hypothesis Available multivariable equations for cardiovascular risk assessment in people with diabetes have been derived either from the general population or from populations with diabetes. Their utility and comparative performance in a contemporary group of patients with type 2 diabetes are not well established. The aim of this study was to evaluate the performance of the Framingham and UK Prospective Diabetes Study (UKPDS) risk equations in participants who took part in the Action in Diabetes and Vascular disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) trial. Methods The 4-year risks of cardiovascular disease (CVD) and its constituents were estimated using two published Framingham and the UKPDS risk equations in 7,502 individuals with type 2 diabetes without prior known CVD at their enrolment in the trial. Conclusions/interpretation Application of the Framingham and UKPDS risk equations to a contemporary treated group of patients with established type 2 diabetes is likely to substantially overestimate cardiovascular risk.

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JO - Diabetologia

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Kengne AP, Patel A, Colagiuri S, Heller S, Hamet P, Marre M et al. The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: The action in diabetes and vascular disease: Pre. Diabetologia. 2010;53(5):821 - 831. doi: 10.1007/s00125-010-1681-4

The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnically diverse sample of patients with diabetes: The action in diabetes and vascular disease: Pre

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