Projects per year
Abstract
The first total synthesis of a polypeptin, PE2, as well as its solution structure is reported. Synthesis in optically pure form confirms the proposed stereochemistry of the polypeptins at the 3-position on the 3-hydroxy depsipeptide moiety. We have also determined the NMR structure of PE2 in aqueous solution, showing it to form a stable ring conformation. The synthetic peptide shows anti-bacterial activity consistent with reports for naturally derived counterparts.
Original language | English |
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Pages (from-to) | 7173-7180 |
Number of pages | 8 |
Journal | Organic & Biomolecular Chemistry |
Volume | 15 |
Issue number | 34 |
DOIs | |
Publication status | Published - 2017 |
Projects
- 1 Finished
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Polymyxin-like lipopeptide antibiotics of the future
Velkov, T., Li, J. & Thompson, P.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/14 → 31/12/16
Project: Research