The first practical asymmetric synthesis of R and S-warfarin

Andrea Robinson, Hui Yin Li, John Feaster

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41 Citations (Scopus)

Abstract

A highly efficient synthesis of both enantiomers of warfarin Ia and Ib has been developed by using a novel two step 'chiral switch' strategy and a DuPHOS-Rh(I) catalyzed asymmetric hydrogenation.

Original languageEnglish
Pages (from-to)8321-8324
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number46
DOIs
Publication statusPublished - 11 Nov 1996
Externally publishedYes

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