The first international consensus conference on continuous renal replacement therapy

John A. Kellum, Ravindra L. Mehta, Derek C. Angus, Paul Palevsky, Claudio Ronco, Rinaldo Bellomo, Timothy Bunchman, William Clark, Andrew Davenport, Thomas Depner, R. T.Noel Gibney, John A. Kellum, Paul Kimmel, J. Michael Lazarus, Martine Leblanc, Nathan Levin, Ravindra L. Mehta, Sangeeta Mehta, Patrick T. Murray, Emil P. PaganiniPaul Palevsky, Claudio Ronco, Miet Schetz, Robert A. Star, Ciro Tetta, David Wensley

Research output: Contribution to journalArticleOtherpeer-review

151 Citations (Scopus)


Background. Management of acute renal failure (ARF) in the critically ill is extremely variable and there are no published standards for the provision of renal replacement therapy in this population. We sought to review the available evidence, make evidence-based practice recommendations, and delineate key questions for future study. Methods. We undertook an evidence-based review of the literature on continuous renal replacement therapy (CRRT) using MEDLINE searches. We determined a list of key questions and convened a 2-day consensus conference to develop summary statements via a series of alternatingbreakout and plenary sessions. In these sessions, we identified supporting evidence and generated practice guidelines and/or directions for future research. Results. Of the 46 questions considered, we found consensus for 20. We found inadequate evidence for 21 questions and for the remaining five we found data but no consensus. Full versions of workgroup findings are available on the Internet at Conclusions. Despite limited data, broad areas of consensus exist for use of CRRT and guideline development appears feasible. Equally broad areas of disagreement also exist and additional basic and applied research in acute renal failure is needed.

Original languageEnglish
Pages (from-to)1855-1863
Number of pages9
JournalKidney International
Issue number5
Publication statusPublished - 1 Jan 2002
Externally publishedYes


  • Acute renal failure
  • Continuous renal replacement therapy
  • Continuous venovenous hemofiltration
  • Hemodialysis

Cite this