Collection of multi-institutional data pertaining to the treatment of bowel cancer has been hindered by poor clinician compliance with data entry and the lack of incentive to participate. Objective: This study aimed to establish if a novel browser-based model of data collection results in complete data capture. Design: A Web-based data collection interface was custom written, offering automated reporting modules for clinical outcome to participants and an automated reporting system for outstanding data fields, and summary reporting of surgical quality outcomes. The software was combined with a clinical feedback system incorporating fortnightly data review meetings, at the time of clinical multidisciplinary meetings. Patients And Setting: Selected were 932 consecutive patients with opt-out consent from 3 hospital sites, including public and private medicine. Main Outcome Measures: The primary outcomes measured were the analysis of data completeness and accuracy and ensuring that the highest-quality data were used for clinical audit of the surgical practices of Australian colorectal surgeons for the purpose of quality assurance. Results: A total of 932 men and women, 22 to 94 years of age, treated for colorectal neoplasia were evaluated. We obtained 100 completion (>27,000 data points) of perioperative data registered by 8 specialist colorectal surgeons and a full-time database manager.