The fidelity, occasional promiscuity, and versatility of T cell receptor recognition

Dale I Godfrey, Jamie Rossjohn, James McCluskey

Research output: Contribution to journalArticleResearchpeer-review

93 Citations (Scopus)


Although there are multiple structures showing how alphabeta T cell receptors (TCRs) specifically recognize antigenic peptides bound to the major histocompatibility complex (MHC) molecules (pMHC-I and pMHC-II), we have little data on how TCRs interact with lipid-based antigens presented by members of the CD1 family. Here, we review recent findings in the field of TCR recognition, including TCR-pMHC complexes and the structure of a TCR in complex with CD1d-glycolipid. Collectively, these studies have revealed the versatility of the TCR in recognizing the distinct yet evolutionarily related proteinaceous and lipid-presenting molecules of the immune system.
Original languageEnglish
Pages (from-to)304 - 314
Number of pages11
Issue number3
Publication statusPublished - 2008

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