The fibroblastic T cell niche in lymphoid tissues

Anne L Fletcher, Alfie T Baker, Veronika Lukacs-Kornek, Konstantin Knoblich

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Fibroblastic reticular cells (FRCs) are a necessary immunological component for T cell health. These myofibroblasts are specialized for immune cell support and develop in locations where T and B lymphocyte priming occurs, usually secondary lymphoid organs, but also tertiary lymphoid structures and sites of chronic inflammation. This review describes their dual supportive and suppressive functions and emerging evidence on the co-ordination required to balance these competing roles.

Original languageEnglish
Pages (from-to)110-116
Number of pages7
JournalCurrent Opinion in Immunology
Volume64
DOIs
Publication statusPublished - Jun 2020

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