The fetal hypothalamic-pituitary-adrenal axis: relevance to developmental origins of adult disease

Deborah M Sloboda, John Newnham, Timothy Moss, John Challis

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis for this has begun to be studied in depth and fully understood. This compilation, written by many of the world s leading experts in this exciting field, summarizes these scientific and clinical advances. The link between early development and the onset of many chronic diseases such as coronary heart disease, diabetes and osteoporosis, also raises important public health issues. Another fascinating theme in the book concerns evolutionary developmental biology and how the evo-devo debate can cast light on these concepts. Clinicians and scientists alike will all learn a lot about this exciting and emerging field.
Original languageEnglish
Title of host publicationDevelopmental Origins of Health and Disease
EditorsPeter D Gluckman, Mark A Hanson
Place of PublicationUnited States
PublisherCambridge University Press
Pages191 - 205
Number of pages15
ISBN (Print)9780521847438
Publication statusPublished - 2006
Externally publishedYes

Cite this

Sloboda, D. M., Newnham, J., Moss, T., & Challis, J. (2006). The fetal hypothalamic-pituitary-adrenal axis: relevance to developmental origins of adult disease. In P. D. Gluckman, & M. A. Hanson (Eds.), Developmental Origins of Health and Disease (pp. 191 - 205). United States: Cambridge University Press.
Sloboda, Deborah M ; Newnham, John ; Moss, Timothy ; Challis, John. / The fetal hypothalamic-pituitary-adrenal axis: relevance to developmental origins of adult disease. Developmental Origins of Health and Disease. editor / Peter D Gluckman ; Mark A Hanson. United States : Cambridge University Press, 2006. pp. 191 - 205
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Sloboda, DM, Newnham, J, Moss, T & Challis, J 2006, The fetal hypothalamic-pituitary-adrenal axis: relevance to developmental origins of adult disease. in PD Gluckman & MA Hanson (eds), Developmental Origins of Health and Disease. Cambridge University Press, United States, pp. 191 - 205.

The fetal hypothalamic-pituitary-adrenal axis: relevance to developmental origins of adult disease. / Sloboda, Deborah M; Newnham, John; Moss, Timothy; Challis, John.

Developmental Origins of Health and Disease. ed. / Peter D Gluckman; Mark A Hanson. United States : Cambridge University Press, 2006. p. 191 - 205.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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Sloboda DM, Newnham J, Moss T, Challis J. The fetal hypothalamic-pituitary-adrenal axis: relevance to developmental origins of adult disease. In Gluckman PD, Hanson MA, editors, Developmental Origins of Health and Disease. United States: Cambridge University Press. 2006. p. 191 - 205