The fate of stem cells within smart biomaterials and constructs

James Carthew, Matthew Mail, James Collins, Daniel E. Heath, Jessica E. Frith, Amy Gelmi

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

In this chapter, we discuss the mechanisms and design of smart biomaterials and constructs which provide controlled triggers and signals to stem cells. Dynamic biomaterials sensitive to light, ultrasound, magnetic and electrical fields, and thermal changes are capable of physical property changes such as material stiffness, topography, and ligand presentation, in addition to exerting mechanical force or delivering electrical signals. Physical properties have been demonstrated to influence stem cell fate, and through creating dynamic “smart” biomaterials we can mimic the living biophysical environment and provide temporally relevant cues.

Original languageEnglish
Title of host publicationNew Trends in Smart Nanostructured Biomaterials in Health Sciences
EditorsGil Gonçalves, Paula Marques, João Mano
Place of PublicationAmsterdam Netherlands
PublisherElsevier - Mosby
Chapter9
Pages277-324
Number of pages48
Edition1st
ISBN (Electronic)9780323856713
DOIs
Publication statusPublished - 2023

Keywords

  • Bioengineering
  • Biomaterials
  • Biomedical engineering
  • Materials in biotechnology
  • Nanotechnology
  • Stem cells research
  • Tissue engineering

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